FKBP8 is a negative regulator of mouse sonic hedgehog signaling in neural tissues Journal Article
| Authors: | Bulgakov, O. V.; Eggenschwiler, J. T.; Hong, D. H.; Anderson, K. V.; Li, T. |
| Article Title: | FKBP8 is a negative regulator of mouse sonic hedgehog signaling in neural tissues |
| Abstract: | Sonic hedgehog (SHH) is a secreted morphogen that regulates the patterning and growth of many tissues in the developing mouse embryo, including the central nervous system (CNS). We show that a member of the FK506-binding protein family, FKBP8, is an essential antagonist of SHH signaling in CNS development. Loss of FKBP8 causes ectopic and ligand-independent activation of the Shh pathway, leading to expansion of ventral cell fates in the posterior neural tube and suppression of eye development. Although it is expressed broadly, FKBP8 is required to antagonize SHH signaling primarily in neural tissues, suggesting that hedgehog signal transduction is subject to cell-type specific modulation during mammalian development. |
| Keywords: | signal transduction; controlled study; unclassified drug; nonhuman; protein function; animal cell; mouse; phenotype; mammalia; animals; mice; mice, knockout; gene targeting; gene expression; signaling; embryo; sonic hedgehog protein; hedgehog proteins; cell fate; embryo development; embryo pattern formation; immunofluorescence; central nervous system; cell type; animalia; in situ hybridization; molecular cloning; regulatory mechanism; gene disruption; nucleotide sequence; membrane protein; immunoblotting; trans-activators; nervous system development; sonic hedgehog; erinaceidae; body patterning; eye; eye development; neural tube defect; fk 506 binding protein; tacrolimus binding proteins; priority journal; article; fkbp38; fkbp8; neural tube patterning; fk 506 binding protein 8 |
| Journal Title: | Development |
| Volume: | 131 |
| Issue: | 9 |
| ISSN: | 0950-1991 |
| Publisher: | Company of Biologists |
| Date Published: | 2004-05-01 |
| Start Page: | 2149 |
| End Page: | 2159 |
| Language: | English |
| DOI: | 10.1242/dev.01122 |
| PROVIDER: | scopus |
| PUBMED: | 15105374 |
| DOI/URL: | |
| Notes: | Development (Cambridge) -- Cited By (since 1996):64 -- Export Date: 16 June 2014 -- CODEN: DEVPE -- Molecular Sequence Numbers: GENBANK: AY278607, AY278608; -- Source: Scopus |
