Benzo[a]pyrene phenols are more potent inducers of CYP1A1, CYP1B1 and COX-2 than benzo[a]pyrene glucuronides in cell lines derived from the human aerodigestive tract Journal Article
| Authors: | Almahmeed, T.; Boyle, J. O.; Cohen, E. G.; Carew, J. F.; Du, B.; Altorki, N. K.; Kopelovich, L.; Fang, J. L.; Lazarus, P.; Subbaramaiah, K.; Dannenberg, A. J. |
| Article Title: | Benzo[a]pyrene phenols are more potent inducers of CYP1A1, CYP1B1 and COX-2 than benzo[a]pyrene glucuronides in cell lines derived from the human aerodigestive tract |
| Abstract: | In summary, our study provides a mechanism for the increased risk of orolaryngeal cancer in smokers with low-activity UGT genotypes. We have demonstrated that B[a]P phenols are more potent inducers of CYP1A1, CYP1B1 and COX-2 than the corresponding B[a]P glucuronides. These results support the concept of developing chemopreventive agents that induce UGTs such as UGT1A7 and UGT1A10. © Oxford University Press 2004; all rights reserved. |
| Keywords: | controlled study; human cell; carcinoma, squamous cell; cancer risk; chemoprophylaxis; cell line; membrane proteins; genotype; smoking; cell culture; enzyme analysis; cyclooxygenase 2; carcinogenicity; benzo(a)pyrene; phenols; aryl hydrocarbon hydroxylases; cytochrome p450 1b1; mouth mucosa; larynx cancer; tongue; mouth neoplasms; glucuronosyltransferase; mouth cancer; isoenzymes; cytochrome p450 1a1; enzyme induction; cytochrome p-450 cyp1a1; phenol derivative; digestive system; prostaglandin-endoperoxide synthases; glucuronide; humans; human; priority journal; article; benzo[a]pyrene derivative; glucuronides; leukoplakia, oral |
| Journal Title: | Carcinogenesis |
| Volume: | 25 |
| Issue: | 5 |
| ISSN: | 0143-3334 |
| Publisher: | Oxford University Press |
| Date Published: | 2004-05-01 |
| Start Page: | 793 |
| End Page: | 799 |
| Language: | English |
| DOI: | 10.1093/carcin/bgh078 |
| PROVIDER: | scopus |
| PUBMED: | 14729581 |
| DOI/URL: | |
| Notes: | Carcinogenesis -- Cited By (since 1996):8 -- Export Date: 16 June 2014 -- CODEN: CRNGD -- Source: Scopus |
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