Androgen receptor CAG repeat length correlates with semen PSA levels in adolescence Journal Article
| Authors: | Giwercman, Y. L.; Richthoff, J.; Lilja, H.; Anderberg, C.; Abrahamsson, P. A.; Giwercman, A. |
| Article Title: | Androgen receptor CAG repeat length correlates with semen PSA levels in adolescence |
| Abstract: | BACKGROUND. Androgens exert their action through the androgen receptor (AR). The length of the AR CAG repeat is inversely correlated to receptor function and short CAG length might be a risk factor for development of prostate cancer. Our aim was to investigate whether CAG repeat number might have an impact on prostate function in adolescence. METHODS. AR genotyping was performed by direct sequencing of leukocyte DNA from 274 military conscripts. All men underwent endocrine evaluation and semen analysis. RESULTS. PSA in seminal plasma, total sperm count and motility all are inversely correlated with CAG numbers (rho = -0.128, P = 0.038; rho = -0.156, P = 0.010; rho = -0.158, P = 0.011), whereas serum levels of free testosterone (rho = 0.132; P = 0.029) and luteinizing hormone (rho = 0.126; P = 0.037) are positively correlated to CAG length. No correlation between seminal PSA and serum testosterone, neither free nor total, was found. CONCLUSIONS. In adolescence, AR genotype, but not serum testosterone, is associated with the level of seminal PSA. © 2003 Wiley-Liss, Inc. |
| Keywords: | adolescent; adult; prostate specific antigen; genotype; risk factors; prostate-specific antigen; prostatic neoplasms; prostate; correlation analysis; dna; psa; androgen receptor; dna sequence; testosterone blood level; receptors, androgen; testosterone; leukocyte; nucleotide repeat; semen analysis; seminal plasma; spermatozoon count; spermatozoon motility; sequence analysis, dna; adolescence; sperm; luteinizing hormone; semen; army; trinucleotide repeat expansion; humans; human; male; priority journal; article; cag repeats; endocrine function test |
| Journal Title: | Prostate |
| Volume: | 59 |
| Issue: | 3 |
| ISSN: | 0270-4137 |
| Publisher: | John Wiley & Sons |
| Date Published: | 2004-05-15 |
| Start Page: | 227 |
| End Page: | 233 |
| Language: | English |
| DOI: | 10.1002/pros.10366 |
| PROVIDER: | scopus |
| PUBMED: | 15042597 |
| DOI/URL: | |
| Notes: | Prostate -- Cited By (since 1996):17 -- Export Date: 16 June 2014 -- CODEN: PRSTD -- Source: Scopus |
