The effect of smoking status on survival following radiation therapy for non-small cell lung cancer Journal Article
| Authors: | Fox, J. L.; Rosenzweig, K. E.; Ostroff, J. S. |
| Article Title: | The effect of smoking status on survival following radiation therapy for non-small cell lung cancer |
| Abstract: | The dangers of cigarette smoking are numerous and well-known, including the causal relationship to lung cancer. This study investigates the effect that smoking status at initial consultation has on radiation therapy for non-small cell lung cancer (NSCLC). We identified 237 patients treated between 1991 and 2001 with definitive radiation or chemoradiation who had complete smoking histories. Median age was 73, with 56% males. Distribution by stage was as follows: I/II - 27%, IIIA - 27%, IIIB - 45%, recurrent - 1%. Two-year overall survival, stratified by stage of disease, was calculated from the time of initiation of treatment. Median follow-up time from the end of treatment was 13 months. Among those with stage I/II disease, current smokers had a 2-year survival rate of 41% and a median survival of 13.7 months while non-smokers had a 2-year survival of 56% and a median survival of 27.9 months (P=0.01). Patients with stage III disease did not show any significant differences in overall survival. There were no significant differences in cancer-specific survival in either stage. In conclusion, among NSCLC patients diagnosed with early stage disease, current smokers have a poorer prognosis for survival after radiation therapy. © 2003 Elsevier Ireland Ltd. All rights reserved. |
| Keywords: | survival; adult; cancer chemotherapy; cancer survival; controlled study; treatment outcome; aged; middle aged; survival analysis; survival rate; major clinical study; cigarette smoking; cancer patient; cancer radiotherapy; combined modality therapy; cancer staging; follow up; neoplasm staging; lung non small cell cancer; carcinoma, non-small-cell lung; lung neoplasms; radiotherapy; smoking; survival time; disease severity; consultation; radiation therapy; platinum derivative; tobacco; non-small cell lung cancer; calculation; humans; prognosis; human; male; female; priority journal; article |
| Journal Title: | Lung Cancer |
| Volume: | 44 |
| Issue: | 3 |
| ISSN: | 0169-5002 |
| Publisher: | Elsevier Ireland Ltd. |
| Date Published: | 2004-06-01 |
| Start Page: | 287 |
| End Page: | 293 |
| Language: | English |
| DOI: | 10.1016/j.lungcan.2003.11.012 |
| PROVIDER: | scopus |
| PUBMED: | 15140541 |
| DOI/URL: | |
| Notes: | Lung Cancer -- Cited By (since 1996):40 -- Export Date: 16 June 2014 -- CODEN: LUCAE -- Source: Scopus |
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