Intensity-modulated radiation therapy (IMRT) for inoperable non-small cell lung cancer: The Memorial Sloan-Kettering Cancer Center (MSKCC) experience Journal Article
| Authors: | Sura, S.; Gupta, V.; Yorke, E.; Jackson, A.; Amols, H.; Rosenzweig, K. E. |
| Article Title: | Intensity-modulated radiation therapy (IMRT) for inoperable non-small cell lung cancer: The Memorial Sloan-Kettering Cancer Center (MSKCC) experience |
| Abstract: | Introduction: Intensity-modulated radiation therapy (IMRT) is an advanced treatment delivery technique that can improve the therapeutic dose ratio. Its use in the treatment of inoperable non-small cell lung cancer (NSCLC) has not been well studied. This report reviews our experience with IMRT for patients with inoperable NSCLC. Methods and materials: We performed a retrospective review of 55 patients with stage I-IIIB inoperable NSCLC treated with IMRT at our institution between 2001 and 2005. The study endpoints were toxicity, local control, and overall survival. Results: With a median follow-up of 26 months, the 2-year local control and overall survival rates for stage I/II patients were 50% and 55%, respectively. For the stage III patients, 2-year local control and overall survival rates were 58% and 58%, respectively, with a median survival time of 25 months. Six patients (11%) experienced grade 3 acute pulmonary toxicity. There were no acute treatment-related deaths. Two patients (4%) had grade 3 or worse late treatment-related pulmonary toxicity. Conclusions: IMRT treatment resulted in promising outcomes for inoperable NSCLC patients. © 2008 Elsevier Ireland Ltd. All rights reserved. |
| Keywords: | cancer survival; treatment outcome; survival rate; retrospective studies; major clinical study; overall survival; intensity modulated radiation therapy; cancer staging; follow up; neoplasm staging; lung toxicity; lung non small cell cancer; carcinoma, non-small-cell lung; lung neoplasms; radiotherapy dosage; tomography, x-ray computed; retrospective study; survival time; intensity-modulated radiotherapy; radiotherapy, intensity-modulated; local control; inoperable cancer; non-small cell lung cancer; inoperable lung non small cell cancer |
| Journal Title: | Radiotherapy and Oncology |
| Volume: | 87 |
| Issue: | 1 |
| ISSN: | 0167-8140 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2008-04-01 |
| Start Page: | 17 |
| End Page: | 23 |
| Language: | English |
| DOI: | 10.1016/j.radonc.2008.02.005 |
| PUBMED: | 18343515 |
| PROVIDER: | scopus |
| PMCID: | PMC2722446 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 29" - "Export Date: 17 November 2011" - "CODEN: RAOND" - "Source: Scopus" |
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