Stereotactic body radiation therapy for sarcoma pulmonary metastases Journal Article
| Authors: | Lebow, E. S.; Lobaugh, S. M.; Zhang, Z.; Dickson, M. A.; Rosenbaum, E.; D'Angelo, S. P.; Nacev, B. A.; Shepherd, A. F.; Shaverdian, N.; Wolden, S.; Wu, A. J.; Gelblum, D. Y.; Simone, C. B. 2nd; Gomez, D. R.; Alektiar, K.; Tap, W. D.; Rimner, A. |
| Article Title: | Stereotactic body radiation therapy for sarcoma pulmonary metastases |
| Abstract: | Background/Purpose: Stereotactic body radiation therapy (SBRT) is standard for patients with inoperable early-stage NSCLC. We hypothesized that SBRT for sarcoma pulmonary metastases would achieve high rates of local control with acceptable toxicity and that patients with oligometastatic disease may achieve prolonged survival following SBRT. Materials/Methods: This retrospective review included consecutive patients at our institution treated with SBRT for sarcoma pulmonary metastases. Cumulative incidence of local failure (LF) was estimated using a competing risks framework. Results: We identified 66 patients treated to 95 pulmonary metastases with SBRT. The median follow-up from the time of SBRT was 36 months (95% CI 34 – 53 months). The cumulative incidence of LF at 12 and 24 months was 3.1% (95% CI 0.9 – 10.6%) and 7.4% (95% CI 4.0% - 13.9%), respectively. The 12- and 24-month overall survival was 74% (95% CI 64 – 86%) and 49% (38 – 63%), respectively. Oligometastatic disease, intrathoracic only disease, and performance status were associated with improved survival on univariable analysis. Three patients had grade 2 pneumonitis, and one patient had grade 2 esophagitis. No patients had ≥ grade 3+ toxicities. Conclusion: To the best of our knowledge, this is the largest series of patients treated with SBRT for pulmonary sarcoma metastases. We observed that SBRT offers an effective alternative to surgical resection with excellent local control and low proportions of toxicity. © 2023 Elsevier B.V. |
| Keywords: | adult; cancer survival; middle aged; treatment failure; major clinical study; overall survival; systemic therapy; cancer patient; cancer radiotherapy; follow up; esophagitis; cohort analysis; retrospective study; risk factor; pneumonia; sarcoma; lung metastasis; patient safety; cancer control; stereotactic body radiation therapy; thorax disease; performance; sbrt; cumulative incidence; pulmonary metastases; immune checkpoint inhibitor; disease burden; human; male; female; article; oligometastatic; ablative radiation therapy; bronchopulmonary sarcoma |
| Journal Title: | Radiotherapy and Oncology |
| Volume: | 187 |
| ISSN: | 0167-8140 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2023-10-01 |
| Start Page: | 109824 |
| Language: | English |
| DOI: | 10.1016/j.radonc.2023.109824 |
| PUBMED: | 37532104 |
| PROVIDER: | scopus |
| PMCID: | PMC11225867 |
| DOI/URL: | |
| Notes: | Article -- Source: Scopus |
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