Criticality accident dosimetry by chromosomal analysis Journal Article
| Authors: | Voisin, P.; Roy, L.; Hone, P. A.; Edwards, A. A.; Lloyd, D. C.; Stephan, G.; Romm, H.; Groer, P. G.; Brame, R. |
| Article Title: | Criticality accident dosimetry by chromosomal analysis |
| Abstract: | The technique of measuring the frequency of dicentric chromosomal aberrations in blood lymphocytes was used to estimate doses in a simulated criticality accident. The simulation consisted of three exposures; ∼5 Gy with a bare source and 1 and 2 Gy with a lead-shielded source. Three laboratories made separate estimates of the doses. These were made by the iterative method of apportioning the observed dicentric frequencies between the gamma and neutron components, taking account of a given gamma/neutron dose ratio, and referring the separated dicentric frequencies to dose-response calibration curves. An alternative method, based on Bayesian ideas, was employed. This was developed for interpreting dicentric frequencies in situations where the gamma/neutron ratio is uncertain. Both methods gave very similar results. One laboratory produced dose estimates close to the eventual exercise reference doses and the other laboratories estimated slightly higher values. The main reason for the higher values was the calibration relationships for fission neutrons. © Oxford University Press 2004; all rights reserved. |
| Keywords: | controlled study; human cell; clinical trial; united states; comparative study; radiation dose; methodology; sensitivity and specificity; reproducibility; reproducibility of results; chromosome; bayes theorem; observer variation; risk factors; pathology; validation study; risk factor; radiation exposure; radiation response; risk assessment; dose-response relationship, radiation; radiation dosage; poisson distribution; health care quality; standard; chromosome aberration; mononuclear cell; leukocytes, mononuclear; evaluation; blood sampling; reference standards; quality assurance, health care; multicenter study; safety; radiometry; relative biological effectiveness; chromosome aberrations; relative biologic effectiveness; lymphocyte; chromosome analysis; germany; chromosomes; france; radiation protection; gamma radiation; safety management; nuclear energy; nuclear safety; accidents, radiation; neutron radiation; radiation accident; humans; human; article; fission neutron; neutron dosimetry; nuclear accident; nuclear reactor; nuclear reactors |
| Journal Title: | Radiation Protection Dosimetry |
| Volume: | 110 |
| Issue: | 1-4 |
| ISSN: | 0144-8420 |
| Publisher: | Oxford University Press |
| Date Published: | 2004-01-01 |
| Start Page: | 443 |
| End Page: | 447 |
| Language: | English |
| DOI: | 10.1093/rpd/nch226 |
| PROVIDER: | scopus |
| PUBMED: | 15353688 |
| DOI/URL: | |
| Notes: | Radiat. Prot. Dosim. -- Cited By (since 1996):14 -- Export Date: 16 June 2014 -- CODEN: RPDOD -- Source: Scopus |
