Relapse after allogeneic hematopoietic cell therapy Journal Article

   


Authors: Van Den Brink, M. R.; Porter, D. L.; Giralt, S.; Lu, S. X.; Jenq, R. R.; Hanash, A.; Bishop, M. R.
Article Title: Relapse after allogeneic hematopoietic cell therapy
Abstract: Disease relapse remains a major cause of mortality following allogeneic hematopoietic cell transplantation (HCT). Over the past decade, our understanding of the biology underlying the graft-versus-tumor/leukemia (GVT) effect has increased greatly; however, several other factors affect the occurrence and outcome of relapse, including conditioning regimen, type of allograft, and the histology, status, and sensitivity to chemotherapy of the disease being treated. The mainstay of relapse treatment is donor lymphocyte infusion (DLI), but the efficacy of DLI is quite variable depending on disease histology and state. As such, there is a significant need for novel therapies and strategies for relapse following allogeneic HCT, particularly in patients for whom DLI is not an option. The National Cancer Institute is sponsoring an international workshop to address issues and research questions relative to the biology, natural history, prevention, and treatment of relapse following allogeneic HCT. Copyright 2010. Published by Elsevier Inc.
Keywords: mortality; review; methodology; t lymphocyte; t-lymphocytes; animal; animals; recurrence; hematopoietic stem cell transplantation; immunology; blood disease; hematologic neoplasms; recurrent disease; graft versus leukemia effect; graft vs tumor effect; lymphocyte transfusion
Journal Title: Biology of Blood and Marrow Transplantation
Volume: 16
Issue: 1 Suppl.
ISSN: 1083-8791
Publisher: Elsevier Inc.  
Date Published: 2010-01-01
Start Page: S138
End Page: 145
Language: English
PUBMED: 19857588
PROVIDER: scopus
DOI: 10.1016/j.bbmt.2009.10.023
PMCID: PMC3637945
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-77953046688&partnerID=40&md5=568ba4bb161f4f4a189720445f6e887e
Notes: --- - "Cited By (since 1996): 1" - "Export Date: 20 April 2011" - "Source: Scopus"
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MSK Authors
  1. Marcel R M Van Den Brink
    616 Van Den Brink
  2. Alan M Hanash
    120 Hanash
  3. Robert R Jenq
    107 Jenq
  4. Sydney X Lu
    100 Lu
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