Effect of cognitive-existential group therapy on survival in early-stage breast cancer Journal Article
| Authors: | Kissane, D. W.; Love, A.; Hatton, A.; Bloch, S.; Smith, G.; Clarke, D. M.; Miach, P.; Ikin, J.; Ranieri, N.; Snyder, R. D. |
| Article Title: | Effect of cognitive-existential group therapy on survival in early-stage breast cancer |
| Abstract: | Purpose: Cognitive-existential group therapy (CEGT) was developed to improve mood and mental attitude toward cancer in women with early-stage breast cancer receiving adjuvant chemotherapy. Given the debate about group therapy's association with increased survival in women with metastatic breast cancer, we were curious to check its effect at a much earlier stage in the cancer journey. Patients and Methods: We randomly assigned 303 women with early-stage breast cancer who were receiving adjuvant chemotherapy to either 20 sessions of weekly group therapy plus three relaxation classes (n = 154) or to a control condition of three relaxation classes alone (n = 149). The primary outcome was survival. Results: CEGT did not extend survival; the median survival time was 81.9 months (95% CI, 64.8 to 99.0 months) in the group-therapy women and 85.5 months (95% CI, 67.5 to 103.6 months) in the control arm. The hazard ratio for death was 1.35 (95% CI, 0.76 to 2.39; P = .31). In contrast, histology and axillary lymph node status were significant predictors of survival. Low-grade histology yielded a hazard ratio of 0.342 (95% CI, 0.17 to 0.69), and axillary lymph node-negative status yielded a hazard ratio of 0.397 (95% CI, 0.20 to 0.78). Conclusion: CEGT does not prolong survival in women with early-stage breast cancer. © 2004 by American Society of Clinical Oncology. |
| Keywords: | survival; adult; cancer survival; controlled study; treatment outcome; aged; middle aged; survival analysis; patient satisfaction; major clinical study; clinical trial; cancer adjuvant therapy; chemotherapy, adjuvant; antineoplastic agent; controlled clinical trial; breast cancer; randomized controlled trial; proportional hazards models; attitude to health; breast neoplasms; histology; cancer mortality; axillary lymph node; adaptive behavior; psychological aspect; social support; adaptation, psychological; affect; proportional hazards model; adjuvant chemotherapy; breast tumor; cognitive therapy; relaxation training; existentialism; psychotherapy, group; group therapy; hazard assessment; humans; human; female; priority journal; article |
| Journal Title: | Journal of Clinical Oncology |
| Volume: | 22 |
| Issue: | 21 |
| ISSN: | 0732-183X |
| Publisher: | American Society of Clinical Oncology |
| Date Published: | 2004-11-01 |
| Start Page: | 4255 |
| End Page: | 4260 |
| Language: | English |
| DOI: | 10.1200/jco.2004.12.129 |
| PROVIDER: | scopus |
| PUBMED: | 15452189 |
| DOI/URL: | |
| Notes: | J. Clin. Oncol. -- Cited By (since 1996):62 -- Export Date: 16 June 2014 -- CODEN: JCOND -- Source: Scopus |
