Supportive-expressive group therapy for women with metastatic breast cancer: Survival and psychosocial outcome from a randomized controlled trial Journal Article
| Authors: | Kissane, D. W.; Grabsch, B.; Clarke, D. M.; Smith, G. C.; Love, A. W.; Bloch, S.; Snyder, R. D.; Li, Y. |
| Article Title: | Supportive-expressive group therapy for women with metastatic breast cancer: Survival and psychosocial outcome from a randomized controlled trial |
| Abstract: | Background: Mixed reports exist about the impact of supportive-expressive group therapy (SEGT) on survival. Methods: From 485 women with advanced breast cancer recruited between 1996-2002, 227 (47%) consented and were randomized within an average 10 months of cancer recurrence in a 2:1 ratio to intervention with 1 year or more of weekly SEGT plus three classes of relaxation therapy (147 women) or to control receiving three classes of relaxation therapy (80 women). The primary outcome was survival; psychosocial well-being was appraised secondarily. Analysis was by intention-to-treat. Results: SEGT did not prolong survival (median survival 24.0 months in SEGT and 18.3 in controls; univariate hazard ratio for death 0.92 [95% CI, 0.69-1.26]; multivariate hazard ratio, 1.06 [95% CI, 0.74-1.51]). Significant predictors of survival were treatment with chemotherapy and hormone therapy (p < 0.001), visceral metastases (p < 0.001) and advanced disease at first diagnosis (p < 0.05). SEGT ameliorated and prevented new DSM-IV depressive disorders (p = 0.002), reduced hopeless-helplessness (p = 0.004), trauma symptoms (p = 0.04) and improved social functioning (p = 0.03). Conclusions: SEGT did not prolong survival. It improved quality of life, including treatment of and protection against depression. Copyright © 2007 John Wiley & Sons, Ltd. |
| Keywords: | survival; adult; cancer chemotherapy; cancer survival; controlled study; aged; middle aged; survival rate; major clinical study; clinical trial; cancer recurrence; advanced cancer; cancer patient; outcome assessment; metastasis; quality of life; controlled clinical trial; neoplasm recurrence, local; breast cancer; randomized controlled trial; diagnostic and statistical manual of mental disorders; psychology; breast neoplasms; cancer hormone therapy; survival time; psychological aspect; social support; depression; death; severity of illness index; patient compliance; visceral metastasis; hazard ratio; neoplasms, second primary; social aspect; relaxation training; intestinal neoplasms; psychotherapy, group; cost of illness; group therapy; wellbeing; hopelessness; depressive disorder, major; social interaction; expressed emotion; psychosocial outcome; helplessness; relaxation techniques |
| Journal Title: | Psycho-Oncology |
| Volume: | 16 |
| Issue: | 4 |
| ISSN: | 1057-9249 |
| Publisher: | John Wiley & Sons |
| Date Published: | 2007-04-01 |
| Start Page: | 277 |
| End Page: | 286 |
| Language: | English |
| DOI: | 10.1002/pon.1185 |
| PUBMED: | 17385190 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 63" - "Export Date: 17 November 2011" - "CODEN: POJCE" - "Source: Scopus" |
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