Development of CD1d-restricted NKT cells in the mouse thymus Journal Article

  


Authors: Dao, T.; Guo, D.; Ploss, A.; Stolzer, A.; Saylor, C.; Boursalian, T. E.; Im, J. S.; Sant'angelo, D. B.
Article Title: Development of CD1d-restricted NKT cells in the mouse thymus
Abstract: Using genetic and phenotypic analyses, we have analyzed the developmental pathway of mouse CD1d-restricted invariant NKT cells. We provide strong evidence that similar to conventional T cells, positive selection of NKT cells occurs during a CD4+CD8+ stage. Later stages of NKT cell development involved the down-regulation of both TCR and CD4 levels and therefore diverge from conventional T cell development pathways. A unique and complete dependency for development on Fyn, a Src family kinase member, also distinguishes the NKT cell and conventional T cell populations. © 2004 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
Keywords: controlled study; proto-oncogene proteins; nonhuman; genetic analysis; cd8 antigen; t lymphocyte; t-lymphocytes; animal cell; mouse; phenotype; animals; mice; cell maturation; cell differentiation; protein tyrosine kinase; mice, transgenic; t lymphocyte receptor; thymus; receptors, antigen, t-cell; thymus gland; natural killer cell; killer cells, natural; down regulation; cd4 antigen; protein family; src-family kinases; developmental stage; t lymphocyte subpopulation; cell selection; cd1d antigen; protein kinase fyn; proto-oncogene proteins c-fyn; t cell receptor; antigens, cd1; cd1d; priority journal; article; inkt cells
Journal Title: European Journal of Immunology
Volume: 34
Issue: 12
ISSN: 0014-2980
Publisher: Wiley V C H Verlag Gmbh  
Date Published: 2004-12-01
Start Page: 3542
End Page: 3552
Language: English
DOI: 10.1002/eji.200425546
PROVIDER: scopus
PUBMED: 15549774
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-10944230883&partnerID=40&md5=baeb1d202cd2ebcdf3f6ee895090023b
Notes: Eur. J. Immunol. -- Cited By (since 1996):32 -- Export Date: 16 June 2014 -- CODEN: EJIMA -- Source: Scopus
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MSK Authors
  1. Alexander Ploss
    8 Ploss
  2. Derek B Sant'angelo
    46 Sant'angelo
  3. Tao Dao
    81 Dao
  4. Amy L Stolzer
    4 Stolzer
  5. Donglin Guo
    4 Guo
  6. Carolyn Saylor
    1 Saylor
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