Use of ex vivo confocal scanning laser microscopy during Mohs surgery for nonmelanoma skin cancers Journal Article
| Authors: | Chung, V. Q.; Dwyer, P. J.; Nehal, K. S.; Rajadhyaksha, M.; Menaker, G. M.; Charles, C.; Jiang, S. B. |
| Article Title: | Use of ex vivo confocal scanning laser microscopy during Mohs surgery for nonmelanoma skin cancers |
| Abstract: | BACKGROUND. Ex vivo confocal scanning laser microscopy offers rapid optical reflectance imaging of excised tissue without conventional frozen histopathology that can potentially expedite Mohs surgery. OBJECTIVE. The objective was to determine the feasibility of using ex vivo confocal scanning laser microscopy during Mohs surgery for detecting residual basal cell carcinoma and squamous cell carcinoma. METHODS. One-hundred fifteen Stage I Mohs surgery excisions (92 basal cell carcinoma, 23 squamous cell carcinoma) were imaged with acetowhitening and confocal scanning laser microscopy and compared to conventional Mohs frozen histologic sections for normal and tumor features. RESULTS. Large aggregates of residual tumor such as nodular basal cell carcinoma were easily detected by ex vivo confocal scanning laser microscopy, whereas smaller tumor foci were not consistently identified. Confocal morphology of tumor subtypes is described. CONCLUSION. Ex vivo confocal scanning laser microscopy can potentially expedite Mohs surgery in rapidly detecting large nodular basal cell carcinomas without conventional frozen histopathology. Further improvements in instrumentation and image quality are necessary to allow broader application and acceptance of this novel technology in Mohs surgery. |
| Keywords: | controlled study; human tissue; major clinical study; histopathology; squamous cell carcinoma; carcinoma, squamous cell; diagnostic accuracy; preoperative evaluation; treatment indication; basal cell carcinoma; microscopy, confocal; skin neoplasms; skin carcinoma; diagnostic value; image quality; predictive value of tests; new york city; frozen section; carcinoma, basal cell; mohs surgery; chemosurgery; confocal laser microscopy; boston; humans; human; priority journal; article |
| Journal Title: | Dermatologic Surgery |
| Volume: | 30 |
| Issue: | 12 I |
| ISSN: | 1076-0512 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2004-12-01 |
| Start Page: | 1470 |
| End Page: | 1478 |
| Language: | English |
| PROVIDER: | scopus |
| PUBMED: | 15606734 |
| DOI: | 10.1111/j.1524-4725.2004.30505.x |
| DOI/URL: | |
| Notes: | Dermatol. Surg. -- Cited By (since 1996):51 -- Export Date: 16 June 2014 -- CODEN: DESUF C2 - 15606734 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors
-
279Nehal -
223Rajadhyaksha
Related MSK Work