The p73 locus is commonly deleted in non-Hodgkin's lymphomas Journal Article
| Authors: | Stoffel, A.; Filippa, D.; Rao, P. H. |
| Article Title: | The p73 locus is commonly deleted in non-Hodgkin's lymphomas |
| Abstract: | Rearrangements involving the 1p36 chromosomal region occur frequently in NHL, suggesting the existence of tumor suppressor gene(s) that are important in lymphomagenesis. p73 is closely related to the tumor suppressor p53 and maps to the chromosome 1p36 region. Here we report heterozygous deletions of the p73 locus in 25% of FL and 27% of DLBCL cases, as detected by FISH. Immunohistochemical analysis showed that four out of five cases with p73 deletions also exhibited increased Ki67 expression, indicating higher proliferation rates of the tumor cells. Our results demonstrate a high proportion of p73 locus specific deletions in NHL and suggest that deletion of this locus may play a role in the progression of NHL. © 2004 Elsevier Ltd. All rights reserved. |
| Keywords: | immunohistochemistry; adult; clinical article; controlled study; human tissue; aged; gene deletion; dna-binding proteins; ki 67 antigen; antigen expression; cell proliferation; ki-67 antigen; in situ hybridization, fluorescence; incidence; gene locus; heterozygote; nuclear proteins; b cell lymphoma; nonhodgkin lymphoma; fluorescence in situ hybridization; lymphoma, non-hodgkin; heterozygosity; tumor suppressor proteins; tumor cell; loss of heterozygosity; fish; chromosomes, human, pair 1; follicular lymphoma; lymphoma, follicular; genes, tumor suppressor; diffuse large b-cell lymphoma; dlbcl; protein p73; lymphoma, large-cell, diffuse; p73; nhl; humans; human; male; female; priority journal; article; fl; non-hodgkins lymphoma |
| Journal Title: | Leukemia Research |
| Volume: | 28 |
| Issue: | 12 |
| ISSN: | 0145-2126 |
| Publisher: | Elsevier Ltd |
| Date Published: | 2004-12-01 |
| Start Page: | 1341 |
| End Page: | 1345 |
| Language: | English |
| DOI: | 10.1016/j.leukres.2004.04.010 |
| PROVIDER: | scopus |
| PUBMED: | 15475076 |
| DOI/URL: | |
| Notes: | Leuk. Res. -- Cited By (since 1996):11 -- Export Date: 16 June 2014 -- CODEN: LERED -- Source: Scopus |
