Association between aryl hydrocarbon receptor genotype and survival in soft tissue sarcoma Journal Article


Authors: Berwick, M.; Matullo, G.; Song, Y. S.; Guarrera, S.; Dominguez, G.; Orlow, I.; Walker, M.; Vineis, P.
Article Title: Association between aryl hydrocarbon receptor genotype and survival in soft tissue sarcoma
Abstract: Purpose: Accumulating evidence shows that germline polymorphisms may affect survival in cancer. The purpose of this study was to investigate the association between polymorphisms in a group of candidate genes and survival with soft tissue sarcoma. Patients and Methods: We measured single nucleotide polymorphisms in the metabolizing, detoxifying, and DNA repair pathways in 120 newly diagnosed patients with soft tissue sarcoma. We assessed polymorphisms in the aryl hydrocarbon receptor (AhR-Arg554Lys), null variants of the glutathione S-transferase superfamily (GSTM1 and GSTT1), x-ray repair cross-complementing 1 and 3, and Xeroderma pigmentosum, group D (XRCC1-Arg399Gln, XRCC3-Thr241Met, XPD-Lys751Gln). We followed the patients for survival for a median of 7.6 years. Results: Cox proportional hazards models demonstrated that a polymorphism at codon 554 in exon 10 of the AhR was significantly and adversely associated with survival (hazard ratio, 2.2; 95% CI, 1.3 to 3.9; P < .01), even while accounting for major clinical characteristics such as tumor grade, tumor size, anatomic site, and patient age. Conclusion: Further study of the role of the AhR polymorphism is warranted. © 2004 by American Society of Clinical Oncology.
Keywords: adult; cancer survival; controlled study; aged; middle aged; survival rate; single nucleotide polymorphism; genetics; polymorphism, single nucleotide; cancer grading; dna repair; tumor volume; proportional hazards models; genotype; pathology; sarcoma; proportional hazards model; glutathione transferase; soft tissue sarcoma; dna metabolism; xeroderma pigmentosum; genetic polymorphism; aromatic hydrocarbon receptor; receptors, aryl hydrocarbon; glutathione transferase m1; complement component c3; humans; human; male; female; priority journal; article; complement component c1
Journal Title: Journal of Clinical Oncology
Volume: 22
Issue: 19
ISSN: 0732-183X
Publisher: American Society of Clinical Oncology  
Date Published: 2004-10-01
Start Page: 3997
End Page: 4001
Language: English
DOI: 10.1200/jco.2004.10.059
PROVIDER: scopus
PUBMED: 15459223
DOI/URL:
Notes: J. Clin. Oncol. -- Cited By (since 1996):26 -- Export Date: 16 June 2014 -- CODEN: JCOND -- Source: Scopus
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MSK Authors
  1. Marianne Berwick
    119 Berwick
  2. Yan Shuang Song
    9 Song
  3. Irene Orlow
    191 Orlow