Association between aryl hydrocarbon receptor genotype and survival in soft tissue sarcoma Journal Article
| Authors: | Berwick, M.; Matullo, G.; Song, Y. S.; Guarrera, S.; Dominguez, G.; Orlow, I.; Walker, M.; Vineis, P. |
| Article Title: | Association between aryl hydrocarbon receptor genotype and survival in soft tissue sarcoma |
| Abstract: | Purpose: Accumulating evidence shows that germline polymorphisms may affect survival in cancer. The purpose of this study was to investigate the association between polymorphisms in a group of candidate genes and survival with soft tissue sarcoma. Patients and Methods: We measured single nucleotide polymorphisms in the metabolizing, detoxifying, and DNA repair pathways in 120 newly diagnosed patients with soft tissue sarcoma. We assessed polymorphisms in the aryl hydrocarbon receptor (AhR-Arg554Lys), null variants of the glutathione S-transferase superfamily (GSTM1 and GSTT1), x-ray repair cross-complementing 1 and 3, and Xeroderma pigmentosum, group D (XRCC1-Arg399Gln, XRCC3-Thr241Met, XPD-Lys751Gln). We followed the patients for survival for a median of 7.6 years. Results: Cox proportional hazards models demonstrated that a polymorphism at codon 554 in exon 10 of the AhR was significantly and adversely associated with survival (hazard ratio, 2.2; 95% CI, 1.3 to 3.9; P < .01), even while accounting for major clinical characteristics such as tumor grade, tumor size, anatomic site, and patient age. Conclusion: Further study of the role of the AhR polymorphism is warranted. © 2004 by American Society of Clinical Oncology. |
| Keywords: | adult; cancer survival; controlled study; aged; middle aged; survival rate; single nucleotide polymorphism; genetics; polymorphism, single nucleotide; cancer grading; dna repair; tumor volume; proportional hazards models; genotype; pathology; sarcoma; proportional hazards model; glutathione transferase; soft tissue sarcoma; dna metabolism; xeroderma pigmentosum; genetic polymorphism; aromatic hydrocarbon receptor; receptors, aryl hydrocarbon; glutathione transferase m1; complement component c3; humans; human; male; female; priority journal; article; complement component c1 |
| Journal Title: | Journal of Clinical Oncology |
| Volume: | 22 |
| Issue: | 19 |
| ISSN: | 0732-183X |
| Publisher: | American Society of Clinical Oncology |
| Date Published: | 2004-10-01 |
| Start Page: | 3997 |
| End Page: | 4001 |
| Language: | English |
| DOI: | 10.1200/jco.2004.10.059 |
| PROVIDER: | scopus |
| PUBMED: | 15459223 |
| DOI/URL: | |
| Notes: | J. Clin. Oncol. -- Cited By (since 1996):26 -- Export Date: 16 June 2014 -- CODEN: JCOND -- Source: Scopus |
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