Prognostic implications of p53 nuclear overexpression and high proliferation index of Ki-67 in adult soft-tissue sarcomas Journal Article
| Authors: | Drobnjak, M.; Latres, E.; Pollack, D.; Karpeh, M.; Dudas, M.; Woodruff, J. M.; Brennan, M. F.; Cordon-Cardo, C. |
| Article Title: | Prognostic implications of p53 nuclear overexpression and high proliferation index of Ki-67 in adult soft-tissue sarcomas |
| Abstract: | Background: Morphologically similar soft-tissue sarcomas may behave in very different fashions, making it difficult to predict clinical outcomes and to properly design therapeutic interventions. In a preliminary study, we observed that TP53 mutations and nuclear overexpression of p53 protein were frequent events in soft-tissue sarcoma, and we noticed an association between p53-positive phenotype and poor clinical outcome. Purpose: We examined the potential clinical relevance of p53 overexpression in adults with soft-tissue sarcomas. We also studied the clinical implications of a high proliferation index. Methods: A cohort of 174 adults with soft-tissue sarcomas were analyzed using anti-p53 and anti- Ki-67 antibodies and immunohistochemical assays on consecutive fresh frozen tissue samples. Results: We observed a significant association between p53 nuclear overexpression and tumor grade (P = .001) and tumor size (P = .01). Patients displaying a p53- positive phenotype had significantly reduced survival (P = .02). Similarly, a significant difference was observed between high proliferation index and tumor grade (P<.001) and reduced patient survival (P = .03). A high Ki-67 proliferation index was detected in association with p53 nuclear overexpression. Conclusions: Overexpression of p53 protein and a high proliferation index strongly correlate with poor clinical outcome and reduced survival in patients having soft-tissue sarcomas. [J Natl Cancer Inst 86:549-554,1994]. © 1994 Oxford University Press. |
| Keywords: | immunohistochemistry; adult; cancer survival; human tissue; survival analysis; human cell; cancer grading; antigen expression; cell proliferation; ki-67 antigen; phenotype; cell cycle; gene expression; tumor volume; neoplasm proteins; genetic transcription; protein p53; nuclear proteins; sarcoma; antibodies, monoclonal; predictive value of tests; soft tissue sarcoma; tumor suppressor protein p53; nuclear overhauser effect; humans; prognosis; human; article |
| Journal Title: | JNCI: Journal of the National Cancer Institute |
| Volume: | 86 |
| Issue: | 7 |
| ISSN: | 0027-8874 |
| Publisher: | Oxford University Press |
| Date Published: | 1994-04-06 |
| Start Page: | 549 |
| End Page: | 554 |
| Language: | English |
| DOI: | 10.1093/jnci/86.7.549 |
| PROVIDER: | scopus |
| PUBMED: | 8133539 |
| DOI/URL: | |
| Notes: | Export Date: 14 January 2019 -- Article -- CODEN: JNCIA C2 -- Source: Scopus |
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