Steroid receptor coactivator-3 regulates glucose metabolism in bladder cancer cells through coactivation of hypoxia inducible factor 1α Journal Article

   


Authors: Zhao, W.; Chang, C.; Cui, Y.; Zhao, X.; Yang, J.; Shen, L.; Zhou, J.; Hou, Z.; Zhang, Z.; Ye, C.; Hasenmayer, D.; Perkins, R.; Huang, X.; Yao, X.; Yu, L.; Huang, R.; Zhang, D.; Guo, H.; Yan, J.
Article Title: Steroid receptor coactivator-3 regulates glucose metabolism in bladder cancer cells through coactivation of hypoxia inducible factor 1α
Abstract: Background: Steroid receptor coactivator-3 (SRC-3) is frequently overexpressed in human urinary bladder cancer. Results: SRC-3 promotes urinary bladder cancer (UBC) cells proliferation through coactivating HIF1 and up-regulating the expression of genes involved in the glycolytic pathway. Conclusion: SRC-3 plays an important role in UBC development through enhancing glycolysis. Significance: Targeting SRC-3 or enzymes in glycolytic pathway could be an attractive approach in UBC therapy. © 2014 by The American Society for Biochemistry and Molecular Biology, Inc.
Keywords: controlled study; human tissue; protein expression; human cell; promoter region; nonhuman; binding affinity; protein function; cell proliferation; mouse; animal tissue; gene; gene expression; protein protein interaction; animal experiment; animal model; bladder cancer; gene expression regulation; cancer cell; lactate dehydrogenase; cycline; steroid receptors; hypoxia inducible factor 1alpha; glycolysis; bladder carcinogenesis; diseases; metabolic regulation; glucose transporter 1; molecular pathology; glucose metabolism; hypoxia-inducible factor 1; steroid receptor coactivator 3; human; priority journal; article; bladder cancer cells; co-activation; glycolytic pathways; urinary bladder cancer; glut1 gene; pgk1 gene
Journal Title: Journal of Biological Chemistry
Volume: 289
Issue: 16
ISSN: 0021-9258
Publisher: American Society for Biochemistry and Molecular Biology  
Date Published: 2014-04-18
Start Page: 11219
End Page: 11229
Language: English
DOI: 10.1074/jbc.M113.535989
PROVIDER: scopus
PMCID: PMC4036260
PUBMED: 24584933
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84899021999&partnerID=40&md5=101fbdee38fe1868ddc9605de080477d
Notes: J. Biol. Chem. -- Export Date: 2 June 2014 -- CODEN: JBCHA -- Source: Scopus
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