Pretransplantation fluorine-18-deoxyglucose-positron emission tomography scan lacks prognostic value in chemosensitive B cell non-hodgkin lymphoma patients undergoing nonmyeloablative allogeneic stem cell transplantation Journal Article

   

Authors:	Sauter, C. S.; Lechner, L.; Scordo, M.; Zheng, J.; Devlin, S. M.; Fleming, S. E.; Castro-Malaspina, H.; Moskowitz, C. H.
Article Title:	Pretransplantation fluorine-18-deoxyglucose-positron emission tomography scan lacks prognostic value in chemosensitive B cell non-hodgkin lymphoma patients undergoing nonmyeloablative allogeneic stem cell transplantation
Abstract:	Whether chemosensitivity, as determined by positron emission tomography using fluorine-18-deoxyglucose (FDG-PET), is a requirement for successful allogeneic hematopoietic stem cell transplantation (allo-SCT) has yet to be established. We analyzed 88 patients with B cell non-Hodgkin lymphoma (B-NHL) for event-free (EFS) and overall survival (OS) according to computed tomography (CT) and FDG-PET criteria before uniform nonmyeloablative (NMA) allo-SCT. Patients who were chemosensitive, according to CT criteria, experienced significantly greater EFS (P < .001) and OS (P < .03) compared with those who were chemorefractory at the time of allo-SCT. Of 58 patients within this cohort who were chemosensitive by CT criteria, there was no difference in EFS (P = .85) or OS (P = .96) between FDG-PET-positive (Deauville 4 to 5, n = 24) and FDG-PET-negative (Deauville 1 to 3, n = 34) patients. There was no difference in survival according to age < or ≥ 60 years, prior autologous-stem cell transplantation, allograft characteristics, or histology. FDG-PET adds no prognostic value in chemosensitive B-NHL before NMA-allo-SCT. © 2014 American Society for Blood and Marrow Transplantation.
Keywords:	allogeneic transplant; b cell non-hodgkin lymphoma; fluorine-18-deoxyglucose-positron emission tomography (fdg-pet) scan
Journal Title:	Biology of Blood and Marrow Transplantation
Volume:	20
Issue:	6
ISSN:	1083-8791
Publisher:	Elsevier Inc.
Date Published:	2014-06-01
Start Page:	881
End Page:	903
Language:	English
DOI:	10.1016/j.bbmt.2014.02.009
PROVIDER:	scopus
PUBMED:	24534109
PMCID:	PMC5716350
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-84899912390&partnerID=40&md5=ab2edbf909b6994f8ec1393227e64177
Notes:	Biol. Blood Marrow Transplant. -- Export Date: 2 June 2014 -- CODEN: BBMTF -- Source: Scopus

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