Prognostic value of FDG-PET prior to autologous stem cell transplantation for relapsed and refractory diffuse large B-cell lymphoma Journal Article


Authors: Sauter, C. S.; Matasar, M. J.; Meikle, J.; Schoder, H.; Ulaner, G. A.; Migliacci, J. C.; Hilden, P.; Devlin, S. M.; Zelenetz, A. D.; Moskowitz, C. H.
Article Title: Prognostic value of FDG-PET prior to autologous stem cell transplantation for relapsed and refractory diffuse large B-cell lymphoma
Abstract: High-dose chemotherapy (HDT) plus autologous stem cell transplantation (ASCT) is the standard of care for chemosensitive relapsed and refractory diffuse large B-cell lymphoma (rel/ref DLBCL). Interim restaging with functional imaging by positron emission tomography using 18F-deoxyglucose (FDG-PET) has not been established after salvage chemotherapy (ST) and before HDT-ASCT by modern criteria. Herein, we evaluated 129 patients with rel/ref DLBCL proceeding to HDT-ASCT, with ST response assessment by FDG-PET according to the contemporary Deauville 5-point scale. At 3 years, patients achieving a Deauville response of 1 to 3 to ST experienced superior progression-free survival (PFS) and overall survival (OS) rates of 77% and 86%, respectively, compared with patients achieving Deauville 4 (49% and 54%, respectively) (P < .001). No other pre-HDT-ASCT risk factors significantly impacted PFS or OS. Despite achieving remission to ST, patients with Deauville 4 should be the focus of risk-adapted investigational therapies. © 2015 by The American Society of Hematology.
Journal Title: Blood
Volume: 125
Issue: 16
ISSN: 0006-4971
Publisher: American Society of Hematology  
Date Published: 2015-04-16
Start Page: 2579
End Page: 2581
Language: English
DOI: 10.1182/blood-2014-10-606939
PROVIDER: scopus
PUBMED: 25758829
PMCID: PMC4624450
DOI/URL:
Notes: Export Date: 4 May 2015 -- Source: Scopus
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MSK Authors
  1. Gary Ulaner
    84 Ulaner
  2. Craig Moskowitz
    373 Moskowitz
  3. Heiko Schoder
    285 Schoder
  4. Craig Steven Sauter
    158 Sauter
  5. Andrew D Zelenetz
    551 Zelenetz
  6. Matthew J Matasar
    119 Matasar
  7. Jessica Lea Meikle
    4 Meikle
  8. Sean McCarthy Devlin
    288 Devlin
  9. Patrick Dale Hilden
    82 Hilden