Multicenter case series of indolent small/medium-sized CD8+ lymphoid proliferations with predilection for the ear and face Journal Article
| Authors: | Li, J. Y.; Guitart, J.; Pulitzer, M. P.; Subtil, A.; Sundram, U.; Kim, Y.; Deonizio, J.; Myskowski, P. L.; Moskowitz, A.; Horwitz, S.; Querfeld, C. |
| Article Title: | Multicenter case series of indolent small/medium-sized CD8+ lymphoid proliferations with predilection for the ear and face |
| Abstract: | We report 7 cases of a CD8 lymphoid proliferation of the ear and face with a cytotoxic T-cell phenotype, but an indolent clinical course. All patients presented with stable or slowly growing asymptomatic lesions on the ear, nose, or lower eyelid. Histopathology showed a dense diffuse dermal infiltrate of small- to medium-sized atypical lymphocytes without destructive features. The lymphocytes were positive for CD3, CD8, β-F1, and TIA-1 and negative for CD4, CD30, CD56, granzyme B, and PD-1. Of note, the proliferation index was low in available cases. All patients remained in complete remission at median follow-up of 14 months regardless of treatment modality. Staging was negative for extracutaneous disease in all patients. The clinically indolent behavior and histopathologic phenotype together with a low proliferation index (10%-15%) emphasize the importance of accurate diagnosis and appropriate clinical management to avoid overtreatment and complications of therapy. © 2014 Lippincott Williams & Wilkins. |
| Keywords: | ear; face; indolent; cytotoxic granules; low proliferation index |
| Journal Title: | American Journal of Dermatopathology |
| Volume: | 36 |
| Issue: | 5 |
| ISSN: | 0193-1091 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2014-05-01 |
| Start Page: | 402 |
| End Page: | 408 |
| Language: | English |
| DOI: | 10.1097/DAD.0b013e3182a74c7a |
| PROVIDER: | scopus |
| PUBMED: | 24394306 |
| DOI/URL: | |
| Notes: | Am. J. Dermatopathol. -- Export Date: 2 June 2014 -- CODEN: AJDOD -- Source: Scopus |
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