In vivo stepwise multi-photon activation fluorescence imaging of melanin in human skin Conference Paper

  


Authors: Lai, Z.; Gu, Z.; Abbas, S.; Lowe, J.; Sierra, H.; Rajadhyaksha, M.; Dimarzio, C.
Title: In vivo stepwise multi-photon activation fluorescence imaging of melanin in human skin
Conference Title: Three-Dimensional and Multidimensional Microscopy: Image Acquisition and Processing XXI
Abstract: The stepwise multi-photon activated fluorescence (SMPAF) of melanin is a low cost and reliable method of detecting melanin because the activation and excitation can be a continuous-wave (CW) mode near infrared (NIR) laser. Our previous work has demonstrated the melanin SMPAF images in sepia melanin, mouse hair, and mouse skin. In this study, we show the feasibility of using SMPAF to detect melanin in vivo. in vivo melanin SMPAF images of normal skin and benign nevus are demonstrated. SMPAF images add specificity for melanin detection than MPFM images and CRM images. Melanin SMPAF is a promising technology to enable early detection of melanoma for dermatologists. © 2014 SPIE.
Keywords: microscopy; melanin; fluorescence; near-infrared; stepwise multi-photon excitation
Journal Title Proceedings of SPIE
Volume: 8949
Conference Dates: 2014 Feb 3-6
Conference Location: San Francisco, CA
ISBN: 0277-786X
Publisher: SPIE  
Location: San Francisco, CA
Date Published: 2014-02-01
Start Page: 894919
Language: English
DOI: 10.1117/12.2038310
PROVIDER: scopus
DOI/URL:

http://www.scopus.com/inward/record.url?eid=2-s2.0-84900455362&partnerID=40&md5=e13472f85e48d9a48eb1cb44584526cf
Notes: Progr. Biomed. Opt. Imaging Proc. SPIE -- Conference code: 104992 -- Export Date: 2 June 2014 -- 3 February 2014 through 6 February 2014 -- Source: Scopus
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MSK Authors
  1. Milind Rajadhyaksha
    222 Rajadhyaksha
  2. Heidy Sierra Gil
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