Effect of hemodialysis on the plasma levels of clofarabine Journal Article
| Authors: | Steinherz, P. G.; Shukla, N.; Kobos, R.; Latcha, S. |
| Article Title: | Effect of hemodialysis on the plasma levels of clofarabine |
| Abstract: | Clofarabine, a nucleoside analogue for treatment of relapsed leukemia, is 50-60% excreted in urine. Clofarabine has not been studied in patients on hemodialysis. We measured levels in one patient in acute renal failure. Prior to dialysis, 43 hr after a 40 mg/m2 infusion, plasma concentration was 139 ng/ml. One hour after begining hemodialysis, a 20 mg/m2 infusion began. Plasma concentrations were 84.2, 81.1, and 88.0 ng/ml while the dialysis and clofarabine infusion occurred simultaneously. Post-dialysis, while the clofarabine was still infusing, the level was 95.8 ng/ml. Hemodialysis does decrease clofarabine levels, but given its large volume distribution, hemodialysis may not be effective for clofarabine overdose. © 2010 Wiley-Liss, Inc. |
| Keywords: | adult; treatment outcome; young adult; unclassified drug; acute granulocytic leukemia; leukemia, myeloid, acute; case report; side effect; topotecan; dexamethasone; thiotepa; fever; tumor lysis syndrome; acute kidney failure; acute leukemia; drug blood level; leukocyte count; drug metabolite; navelbine; leukemia relapse; blood clotting disorder; hemodialysis; renal failure; uric acid; uric acid blood level; clofarabine; leukemia remission; respiratory distress; 6 ketoclofarabine; rasburicase; diabetic ketoacidosis; dialysate; drug disposition; oliguria; adenine nucleotides; arabinonucleosides; kidney failure, acute; renal dialysis |
| Journal Title: | Pediatric Blood and Cancer |
| Volume: | 55 |
| Issue: | 1 |
| ISSN: | 1545-5009 |
| Publisher: | Wiley Periodicals, Inc |
| Date Published: | 2010-07-15 |
| Start Page: | 196 |
| End Page: | 198 |
| Language: | English |
| DOI: | 10.1002/pbc.22458 |
| PUBMED: | 20232428 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 20 April 2011" - "CODEN: PBCEA" - "Source: Scopus" |
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