A pilot clinical/pharmacological study of the protein kinase C-specific inhibitor safingol alone and in combination with doxorubicin Journal Article
| Authors: | Schwartz, G. K.; Ward, D.; Saltz, L.; Casper, E. S.; Spiess, T.; Mullen, E.; Woodworth, J.; Venuti, R.; Zervos, P.; Storniolo, A. M.; Kelsen, D. P. |
| Article Title: | A pilot clinical/pharmacological study of the protein kinase C-specific inhibitor safingol alone and in combination with doxorubicin |
| Abstract: | We performed a pilot clinical trial with safingol (L-threo-dihydrosphingosine), a protein kinase C-specific inhibitor that potentiates the effect of doxorubicin (DOX) in tumor-bearing animals. Safingol was initially administered as a 1-h infusion at escalating doses. Fourteen days later, patients received the same dose of safingol in combination with a fixed dose of DOX. The combination was repeated at 3-week intervals. Safingol dose levels ranged from 15 to 120 mg/m2. The plasma levels achieved at the final dose level were comparable to those associated with potentiation of DOX in animals. The mean C(max) and area under the curve for safingol at the 120 mg/m2 dose level were 1040 ± 196 ng/ml and 1251 ± 317 mg x h/ml, respectively. The mean plasma half-life for safingol was 3.97 ± 2.51 h, the mean estimated clearance was 3140 ± 765 ml/min, and the mean volume of distribution was of 995 ± 421 liters. Coadministration of a fixed dose of DOX did not significantly change the pharmacokinetics of safingol, nor did increasing doses of safingol significantly affect the pharmacokinetics of DOX. Minor responses were observed in three patients with pancreatic cancer and one patient with angiosarcoma of the scalp. This pilot phase I study indicates that the protein kinase C inhibitor safingol can be given safely with 45 mg/m2 of DOX at a dose that is potentially pharmacologically active without dose-limiting toxicity. |
| Keywords: | adult; clinical article; controlled study; aged; middle aged; clinical trial; doxorubicin; antineoplastic agents; pancreas cancer; neoplasms; controlled clinical trial; blood toxicity; leukopenia; thrombocytopenia; antineoplastic combined chemotherapy protocols; drug administration schedule; dose-response relationship, drug; angiosarcoma; drug distribution; pilot projects; enzyme inhibitors; carcinoma; drug clearance; metabolic clearance rate; protein kinase c; phase 1 clinical trial; drug half life; safingol; sphingosine; regression analysis; infusions, intravenous; intravenous drug administration; protein kinase c inhibitor; humans; human; male; female; priority journal; article |
| Journal Title: | Clinical Cancer Research |
| Volume: | 3 |
| Issue: | 4 |
| ISSN: | 1078-0432 |
| Publisher: | American Association for Cancer Research |
| Date Published: | 1997-04-01 |
| Start Page: | 537 |
| End Page: | 543 |
| Language: | English |
| PUBMED: | 9815717 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Article -- Export Date: 17 March 2017 -- Source: Scopus |
Citation Impact
Related MSK Work