Is Mycobacterium tuberculosis stressed out? A critical assessment of the genetic evidence Journal Article
| Authors: | Stallings, C. L.; Glickman, M. S. |
| Article Title: | Is Mycobacterium tuberculosis stressed out? A critical assessment of the genetic evidence |
| Abstract: | Mycobacterium tuberculosis is an obligate human intracellular pathogen which remains a major killer worldwide. A remarkable feature of M. tuberculosis infection is the ability of the pathogen to persist within the host for decades despite an impressive onslaught of stresses. In this review we seek to outline the host-inflicted stresses experienced by M. tuberculosis, the bacterial strategies used to withstand these stresses, and how this information should guide our efforts to combat this global pathogen. © 2010 Institut Pasteur. |
| Keywords: | pathogenesis; nonhuman; genetic analysis; dna damage; stress, physiological; clinical assessment; bacteria (microorganisms); mycobacterium tuberculosis; medical information; reactive oxygen metabolite; short survey; nutrient; phosphate; phagosome; tuberculosis; gene expression regulation, bacterial; starvation; cell surface; host-pathogen interactions; stress responses; reactive nitrogen species; acidification |
| Journal Title: | Microbes and Infection |
| Volume: | 12 |
| Issue: | 14-15 |
| ISSN: | 1286-4579 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2010-12-01 |
| Start Page: | 1091 |
| End Page: | 1101 |
| Language: | English |
| DOI: | 10.1016/j.micinf.2010.07.014 |
| PUBMED: | 20691805 |
| PROVIDER: | scopus |
| PMCID: | PMC3587153 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 20 April 2011" - "CODEN: MCINF" - "Source: Scopus" |
