Genome-wide association studies of cancer predisposition Journal Article
| Authors: | Stadler, Z. K.; Vijai, J.; Thom, P.; Kirchhoff, T.; Hansen, N. A. L.; Kauff, N. D.; Robson, M.; Offit, K. |
| Article Title: | Genome-wide association studies of cancer predisposition |
| Abstract: | Genome-wide association studies (GWAS) have now been performed in nearly all common malignancies and have identified more than 100 common genetic risk variants that confer a modest increased risk of cancer. For most discovered germline risk variants, the per allele effect size is small (<1.5) and the biologic mechanism of the detected association remains unexplained. Exceptions are the risk variants identified in JAK2 in myeloproliferative neoplasm and in the KITLG gene in testicular cancer, which are each associated with nearly a 3-fold increased risk of disease. GWAS have provided an efficient approach to identifying common, low-penetrance risk variants, and have implicated several novel cancer susceptibility loci. However, the identified low-penetrance risk variants explain only a small fraction of the heritability of cancer and the clinical usefulness of using these variants for cancer-risk prediction is to date limited. Studies involving more heterogeneous populations, determination of the causal variants, and functional studies are now necessary to further elucidate the potential biologic and clinical significance of the observed associations. © 2010 Elsevier Inc. |
| Keywords: | gene mutation; single nucleotide polymorphism; review; cancer risk; nonhuman; methotrexate; glioma; neoplasms; colorectal cancer; cancer susceptibility; genetic predisposition to disease; melanoma; ovary cancer; breast cancer; gene expression; basal cell carcinoma; gene locus; genetic association; genetic variability; gene frequency; genome-wide association study; lung cancer; bladder cancer; acute lymphoblastic leukemia; digestive system cancer; prostate cancer; gene mapping; hematologic malignancy; neuroblastoma; testis tumor; thyroid cancer; genetic predisposition; germ cell tumor; genetic testing; cancer predisposition; cancer susceptibility regions; clinical role; gene linkage disequilibrium |
| Journal Title: | Hematology/Oncology Clinics of North America |
| Volume: | 24 |
| Issue: | 5 |
| ISSN: | 0889-8588 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2010-10-01 |
| Start Page: | 973 |
| End Page: | 996 |
| Language: | English |
| DOI: | 10.1016/j.hoc.2010.06.009 |
| PUBMED: | 20816582 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 20 April 2011" - "CODEN: HCNAE" - "Source: Scopus" |
Altmetric
Citation Impact
BMJ Impact Analytics
Related MSK Work