Gastric cancer: A primer on the epidemiology and biology of the disease and an overview of the medical management of advanced disease Journal Article
| Authors: | Shah, M. A.; Kelsen, D. P. |
| Article Title: | Gastric cancer: A primer on the epidemiology and biology of the disease and an overview of the medical management of advanced disease |
| Abstract: | Gastric cancer is a cause of significant morbidity and cancer-related mortality worldwide. Despite recent advances in targeted therapy and understanding of the biology and development of the malignancy, progress in the treatment of gastric cancer has been limited. Most newly diagnosed patients will present with incurable disease, and have a median survival of less than 1 year. Although the disease has widespread ethnic and epidemiologic differences, medical management of gastric cancer does not distinguish among the various disease subtypes. The recent report of the ToGA phase III study has validated Her2 as a molecular target in this disease, supporting the concept that a greater understanding of the biology of gastric cancer subsets may improve treatment selection and overall outcome of individual patients. This article summarizes the epidemiology and ethnic variation of this disease to crystalize subtypes of gastric cancer in the context of current and future medical management of advanced disease. © Journal of the National Comprehensive Cancer Network. |
| Keywords: | cancer survival; overall survival; clinical trial; fatigue; neutropenia; pathogenesis; sorafenib; bevacizumab; cisplatin; doxorubicin; fluorouracil; advanced cancer; cancer combination chemotherapy; cancer risk; drug withdrawal; clinical trials as topic; capecitabine; combined modality therapy; treatment; methotrexate; outcome assessment; gene targeting; metastasis; quality of life; nausea; vomiting; peripheral neuropathy; morbidity; smoking; uvomorulin; cancer mortality; docetaxel; irinotecan; febrile neutropenia; targets; thromboembolism; folinic acid; stomach cancer; epirubicin; sex difference; cancer classification; genetic risk; ethnic difference; trastuzumab; alcohol consumption; mitomycin; oxaliplatin; environmental factor; genetic predisposition; stomach neoplasms; lapatinib; chronic inflammation; gastric cancer; oncogene neu; helicobacter infection; 5 chloro 2,4 dihydroxypyridine plus oxonate potassium plus tegafur; gastric cancer subtypes; salt intake |
| Journal Title: | Journal of the National Comprehensive Cancer Network |
| Volume: | 8 |
| Issue: | 4 |
| ISSN: | 1540-1405 |
| Publisher: | Harborside Press |
| Date Published: | 2010-04-01 |
| Start Page: | 437 |
| End Page: | 447 |
| Language: | English |
| PUBMED: | 20410336 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 6" - "Export Date: 20 April 2011" - "Source: Scopus" |
