Genome destabilization by homologous recombination in the germ line Journal Article
| Authors: | Sasaki, M.; Lange, J.; Keeney, S. |
| Article Title: | Genome destabilization by homologous recombination in the germ line |
| Abstract: | Meiotic recombination, which promotes proper homologous chromosome segregation at the first meiotic division, normally occurs between allelic sequences on homologues. However, recombination can also take place between non-allelic DNA segments that share high sequence identity. Such non-allelic homologous recombination (NAHR) can markedly alter genome architecture during gametogenesis by generating chromosomal rearrangements. Indeed, NAHR-mediated deletions, duplications, inversions and other alterations have been implicated in numerous human genetic disorders. Studies in yeast have provided insights into the molecular mechanisms of meiotic NAHR as well as the cellular strategies that limit it. © 2010 Macmillan Publishers Limited. All rights reserved. |
| Keywords: | gene deletion; review; nonhuman; meiosis; animals; homologous recombination; dna repair; genotype; molecular mechanics; germ cells; germ line; genetic recombination; recombination, genetic; genomic instability; dna breaks, double-stranded; gene duplication; chromosome rearrangement; models, genetic; yeast; genetic disorder; gene structure; gametogenesis |
| Journal Title: | Nature Reviews Molecular Cell Biology |
| Volume: | 11 |
| Issue: | 3 |
| ISSN: | 1471-0072 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2010-03-01 |
| Start Page: | 182 |
| End Page: | 195 |
| Language: | English |
| DOI: | 10.1038/nrm2849 |
| PUBMED: | 20164840 |
| PROVIDER: | scopus |
| PMCID: | PMC3073813 |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 5" - "Export Date: 20 April 2011" - "CODEN: NRMCB" - "Source: Scopus" |
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