Androgen deprivation therapy and estrogen deficiency induced adverse effects in the treatment of prostate cancer Journal Article
| Authors: | Freedland, S. J.; Eastham, J.; Shore, N. |
| Article Title: | Androgen deprivation therapy and estrogen deficiency induced adverse effects in the treatment of prostate cancer |
| Abstract: | Androgen deprivation therapy (ADT) is the standard of care for metastatic prostate cancer and is increasingly used to treat asymptomatic patients with prostate-specific antigen recurrence after failed primary therapy. Although effective, ADT is associated with multiple adverse effects, many of which are related to the estrogen deficiency that occurs as a result of treatment. These include increased fracture risk, hot flashes, gynecomastia, serum lipid changes and memory loss. By providing clinicians with a greater awareness of the estrogen deficiency induced adverse effects from ADT, they can proactively intervene on the physical and psychological impact these effects have on patients. |
| Keywords: | review; side effect; quality of life; estrogens; bone density; risk; prostate cancer; prostatic neoplasms; goserelin; leuprorelin; drug mechanism; androgen antagonists; diethylstilbestrol; hot flush; bicalutamide; flutamide; nilutamide; antineoplastic agents, hormonal; androgen deprivation therapy; degarelix; triptorelin; amnesia; bone remodeling; estrogen deficiency; fragility fracture; gynecomastia; lipid blood level; fractures, bone; gonadotropin-releasing hormone; hot flashes; lipid metabolism; memory disorders; testosterone |
| Journal Title: | Prostate Cancer and Prostatic Diseases |
| Volume: | 12 |
| Issue: | 4 |
| ISSN: | 1365-7852 |
| Publisher: | Nature Publishing Group |
| Date Published: | 2009-01-01 |
| Start Page: | 333 |
| End Page: | 338 |
| Language: | English |
| DOI: | 10.1038/pcan.2009.35 |
| PUBMED: | 19901933 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 6" - "Export Date: 30 November 2010" - "CODEN: PCPDF" - "Source: Scopus" |
