Cardiovascular and metabolic effects of androgen-deprivation therapy for prostate cancer Journal Article

  


Authors: Gupta, D.; Lee Chuy, K.; Yang, J. C.; Bates, M.; Lombardo, M.; Steingart, R. M.
Article Title: Cardiovascular and metabolic effects of androgen-deprivation therapy for prostate cancer
Abstract: Androgen-deprivation therapy (ADT) entails lowering serum testosterone levels to castrate levels and forms a cornerstone of the management of hormone-sensitive advanced prostate cancer; however, the benefit of ADT is partially offset by its detrimental metabolic and cardiovascular adverse effects. ADT decreases insulin sensitivity while promoting dyslipidemia and sarcopenic obesity, which leads to an increased risk of cardiovascular morbidity and potentially mortality. The risk seems to be highest in elderly patients who have had recent cardiovascular events before starting ADT. It is prudent to engage in an individualized risk-benefit discussion and develop a cohesive multidisciplinary management plan to medically optimize and closely observe these patients before and during treatment with ADT.
Journal Title: Journal of Oncology Practice
Volume: 14
Issue: 10
ISSN: 1554-7477
Publisher: American Society of Clinical Oncology  
Date Published: 2018-10-01
Start Page: 580
End Page: 587
Language: English
DOI: 10.1200/jop.18.00178
PUBMED: 30312560
PROVIDER: scopus
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-85054896195&doi=10.1200%2fJOP.18.00178&partnerID=40&md5=6aaef28cb53327e994d2a39be0cabad7
Notes: Article -- Export Date: 1 November 2018 -- Source: Scopus
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MSK Authors
  1. Richard M Steingart
    175 Steingart
  2. Dipti Gupta
    55 Gupta
  3. Katherine Lee Chuy
    10 Lee Chuy
  4. Ji Can Yang
    5 Yang
  5. Megan Carie Bates
    1 Bates
  6. Marissa A Lombardo
    1 Lombardo
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