Primary thrombocytosis in children Journal Article
| Authors: | Kucine, N.; Chastain, K. M.; Mahler, M. B.; Bussel, J. B. |
| Article Title: | Primary thrombocytosis in children |
| Abstract: | Myeloproliferative neoplasms are uncommon disorders in children, for which we have limited understanding of the pathogenesis and optimal management. JAK2 and MPL mutations, while common drivers of myeloproliferative neoplasms in adult patients, are not clearly linked to pediatric disease. Management and clinical outcomes in adults have been well delineated with defined recommendations for risk stratification and treatment. This is not the case for pediatric patients, for whom there is neither a standard approach to workup nor any consensus regarding management. This review will discuss thrombocytosis in children, including causes of thrombocytosis in children, the limited knowledge we have regarding pediatric primary thrombocytosis, and our thoughts on potential risk stratification and management, and future questions to be answered by laboratory research and collaborative clinical study. © Ferrata Storti Foundation. |
| Keywords: | signal transduction; single nucleotide polymorphism; mutation; busulfan; hydroxyurea; janus kinase 2; myeloid metaplasia; review; alpha interferon; gene; stem cell factor; low drug dose; gene expression; erythropoietin; anemia; thrombocytopenia; inflammation; protein bcl xl; chronic myeloid leukemia; cancer therapy; risk; acetylsalicylic acid; interleukin 6; upregulation; bcr abl protein; stat5 protein; myeloproliferative neoplasm; thrombocytosis; polycythemia vera; thrombocythemia; thrombopoietin; randomized controlled trial (topic); phase 1 clinical trial (topic); interleukin 11; interleukin 3; anagrelide; ruxolitinib; megakaryopoiesis; human; cmpl gene; cytoreductive therapy |
| Journal Title: | Haematologica |
| Volume: | 99 |
| Issue: | 4 |
| ISSN: | 0390-6078 |
| Publisher: | Ferrata Storti Foundation |
| Date Published: | 2014-01-01 |
| Start Page: | 620 |
| End Page: | 628 |
| Language: | English |
| DOI: | 10.3324/haematol.2013.092684 |
| PROVIDER: | scopus |
| PMCID: | PMC3971071 |
| PUBMED: | 24688110 |
| DOI/URL: | |
| Notes: | Export Date: 1 May 2014 -- CODEN: HAEMA -- Source: Scopus |
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