Death induced by CD95 or CD95 ligand elimination Journal Article
| Authors: | Hadji, A.; Ceppi, P.; Murmann, A. E.; Brockway, S.; Pattanayak, A.; Bhinder, B.; Hau, A.; De Chant, S.; Parimi, V.; Kolesza, P.; Richards, J.; Chandel, N.; Djaballah, H.; Peter, M. E. |
| Article Title: | Death induced by CD95 or CD95 ligand elimination |
| Abstract: | CD95 (Fas/APO-1), when bound by its cognate ligand CD95L, induces cells to die by apoptosis. We now show that elimination of CD95 or CD95L results in a form of cell death that is independent of caspase-8, RIPK1/MLKL, and p53, is not inhibited by Bcl-xL expression, and preferentially affects cancer cells. All tumors that formed in mouse models of low-grade serous ovarian cancer or chemically induced liver cancer with tissue-specific deletion of CD95 still expressed CD95, suggesting that cancer cannot form in the absence of CD95. Death induced by CD95R/L elimination (DICE) is characterized by an increase incell size, production of mitochondrial ROS, and DNA damage. It resembles a necrotic form of mitotic catastrophe. No single drug was found to completely block this form of cell death, and it could also not be blocked by the knockdown of a single gene, making it a promising way to kill cancer cells. © 2014 The Authors. |
| Journal Title: | Cell Reports |
| Volume: | 7 |
| Issue: | 1 |
| ISSN: | 2211-1247 |
| Publisher: | Cell Press |
| Date Published: | 2014-04-10 |
| Start Page: | 208 |
| End Page: | 222 |
| Language: | English |
| DOI: | 10.1016/j.celrep.2014.02.035 |
| PROVIDER: | scopus |
| PUBMED: | 24656822 |
| PMCID: | PMC4083055 |
| DOI/URL: | |
| Notes: | Export Date: 1 May 2014 -- Source: Scopus |
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