Targeted therapies for treatment of recurrent ovarian cancer Journal Article
| Authors: | Grisham, R. N.; Hyman, D. M.; Iyer, G. |
| Article Title: | Targeted therapies for treatment of recurrent ovarian cancer |
| Abstract: | Ovarian cancer remains the leading cause of death among women with gynecologic malignancies in the United States. Most women with epithelial ovarian cancer present with advanced disease. Despite good response rates to initial surgery and chemotherapy, the majority of patients experience relapse and ultimately die of their disease. A better understanding of the molecular differences underlying the histologic subtypes of epithelial ovarian cancer has led to recent advances in targeted therapeutic strategies. Here we review the most promising targeted therapeutics currently being used for the treatment of recurrent ovarian cancer. |
| Keywords: | signal transduction; mitogen activated protein kinase; unclassified drug; gene mutation; sorafenib; bevacizumab; doxorubicin; placebo; raf protein; sunitinib; gemcitabine; paclitaxel; topotecan; ovarian cancer; dna repair; carboplatin; unindexed drug; vasculotropin receptor; progression free survival; ovary cancer; recurrence; cyclophosphamide; angiogenesis; histology; cancer resistance; alanine aminotransferase; aspartate aminotransferase; tyrosine kinase receptor; vasculotropin a; cediranib; pazopanib; vandetanib; ras protein; ca 125 antigen; nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase; olaparib; targeted therapies; randomized controlled trial (topic); fallopian tube cancer; primary peritoneal cancer; molecularly targeted therapy; phase 2 clinical trial (topic); recurrent ovarian cancer; phase 3 clinical trial (topic); phase 1 clinical trial (topic); selumetinib; veliparib; rucaparib; alisertib; human; article; arry 438162; mk 1775; nintedanib |
| Journal Title: | Clinical Advances in Hematology & Oncology |
| Volume: | 12 |
| Issue: | 3 |
| ISSN: | 1543-0790 |
| Publisher: | Millennium Medical Publishing, Inc |
| Date Published: | 2014-03-01 |
| Start Page: | 158 |
| End Page: | 162 |
| Language: | English |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 1 May 2014 -- Source: Scopus |
