A review of mirvetuximab soravtansine in the treatment of platinum-resistant ovarian cancer Journal Article
| Authors: | Moore, K. N.; Martin, L. P.; O'Malley, D. M.; Matulonis, U. A.; Konner, J. A.; Vergote, I.; Ponte, J. F.; Birrer, M. J. |
| Article Title: | A review of mirvetuximab soravtansine in the treatment of platinum-resistant ovarian cancer |
| Abstract: | Resistance to platinum-based therapy poses a significant clinical challenge for the management of advanced ovarian cancer, a leading cause of cancer mortality among women. Mirvetuximab soravtansine is a novel antibody-drug conjugate that targets folate receptor-α, a validated molecular target for therapeutic intervention in this disease. Here, we examine mirvetuximab soravtansine's mechanism of action and pharmacology, and review its clinical evaluation in ovarian cancer to date. We focus on the favorable tolerability and encouraging signals of efficacy that have emerged, most notably in patients with platinum-resistant disease. Ongoing Phase III monotherapy and Phase Ib/II combination trials evaluating its activity in the setting of platinum resistance are emphasized, which will help define its role in the evolving landscape of ovarian cancer therapy. © 2017 2017 Future Medicine Ltd. |
| Keywords: | cancer survival; protein expression; overall survival; constipation; drug tolerability; fatigue; neutropenia; review; bevacizumab; doxorubicin; diarrhea; drug efficacy; gemcitabine; paclitaxel; topotecan; binding affinity; ovarian cancer; progression free survival; ovary cancer; nausea; thrombocytopenia; antineoplastic activity; docetaxel; immunogenicity; folic acid; platinum complex; internalization; blurred vision; catabolism; hydrophilicity; platinum resistance; novel therapy; antibody-drug conjugate; human; priority journal; pembrolizumab; mirvetuximab soravtansine; folate receptor-α |
| Journal Title: | Future Oncology |
| Volume: | 14 |
| Issue: | 2 |
| ISSN: | 1479-6694 |
| Publisher: | Future Medicine |
| Date Published: | 2018-01-01 |
| Start Page: | 123 |
| End Page: | 136 |
| Language: | English |
| DOI: | 10.2217/fon-2017-0379 |
| PROVIDER: | scopus |
| PUBMED: | 29098867 |
| DOI/URL: | |
| Notes: | Review -- Export Date: 1 February 2018 -- Source: Scopus |
