Genetic alterations and personalized medicine in melanoma: Progress and future prospects Journal Article
| Authors: | Griewank, K. G.; Scolyer, R. A.; Thompson, J. F.; Flaherty, K. T.; Schadendorf, D.; Murali, R. |
| Article Title: | Genetic alterations and personalized medicine in melanoma: Progress and future prospects |
| Abstract: | High-throughput sequencing technologies are providing new insights into the genetic alterations involved in melanomagenesis. It appears likely that most genetic events important in the pathogenesis of melanoma will be discovered over the next few years. Genetic analysis is also increasingly being used to direct patient care. In parallel with the discovery of new genes and the elucidation of molecular pathways important in the development of melanoma, therapies targeting these pathways are becoming available. In other words, the age of personalized medicine has arrived, characterized by molecular profiling of melanoma to identify the relevant genetic alterations and the abnormal signaling mechanisms involved, followed by selection of optimal, individualized therapies. In this review, we summarize the key genetic alterations in melanoma and the development of targeted agents against melanomas bearing specific mutations. These developments in melanoma serve as a model for the implementation of personalized medicine for patients with all cancers. |
| Keywords: | genetics; mutation; review; antineoplastic agents; methodology; antineoplastic agent; phenotype; in situ hybridization, fluorescence; genetic predisposition to disease; melanoma; skin neoplasms; protein kinase inhibitor; genotype; protein kinase inhibitors; skin tumor; fluorescence in situ hybridization; genetic predisposition; genetic screening; comparative genomic hybridization; genetic testing; personalized medicine; molecularly targeted therapy; individualized medicine; molecular targeted therapy; humans; human |
| Journal Title: | JNCI: Journal of the National Cancer Institute |
| Volume: | 106 |
| Issue: | 2 |
| ISSN: | 0027-8874 |
| Publisher: | Oxford University Press |
| Date Published: | 2014-02-05 |
| Start Page: | djt435 |
| Language: | English |
| DOI: | 10.1093/jnci/djt435 |
| PUBMED: | 24511108 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 1 May 2014 -- Source: Scopus |
