Selecting patients for KIT inhibition in melanoma Journal Article
| Authors: | Carvajal, R. D.; Hamid, O.; Antonescu, C. R. |
| Article Title: | Selecting patients for KIT inhibition in melanoma |
| Abstract: | For many years, melanoma has been regarded as a single disease in terms of therapeutic considerations. The more recent identification of multiple molecular mechanisms underlying the development, progression, and prognosis of melanoma has led to a new paradigm for the management of this disease, has created new therapeutic opportunities, and has led to improved clinical outcomes. Such advances, however, are dependent upon methods that can reproducibly identify key molecular alterations within an individual tumor, define clinically relevant genetic subgroups of disease, and permit improved patient selection for targeted therapies. Melanomas harboring genetic alterations of KIT have been demonstrated to constitute one such molecular subgroup of disease. In this chapter, we will discuss the biology of KIT in melanoma, review the rationale for and clinical data regarding KIT inhibition in melanomas harboring activating alterations of KIT, propose guidelines for the selection of patients for KIT inhibitor therapy, and, finally, present laboratory methods for KIT assessment in melanoma. © Springer Science+Business Media New York 2014. |
| Keywords: | imatinib; melanoma; kit; mucosal; acral |
| Journal Title: | Methods in Molecular Biology |
| Volume: | 1102 |
| ISSN: | 1064-3745 |
| Publisher: | Humana Press Inc |
| Publication Place: | New York |
| Date Published: | 2014-01-01 |
| Start Page: | 137 |
| End Page: | 162 |
| Language: | English |
| DOI: | 10.1007/978-1-62703-727-3_9 |
| PROVIDER: | scopus |
| PUBMED: | 24258978 |
| DOI/URL: | |
| Notes: | Chapter 9 in "Molecular Diagnostics for Melanoma: Methods and Protocols" (ISBN: 978-1-62703-726-6) - Export Date: 3 February 2014 -- Source: Scopus |
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