Optimizing autologous stem cell mobilization strategies to improve patient outcomes: Consensus guidelines and recommendations Journal Article
| Authors: | Giralt, S.; Costa, L.; Schriber, J.; DiPersio, J.; Maziarz, R.; McCarty, J.; Shaughnessy, P.; Snyder, E.; Bensinger, W.; Copelan, E.; Hosing, C.; Negrin, R.; Petersen, F. B.; Rondelli, D.; Soiffer, R.; Leather, H.; Pazzalia, A.; Devine, S. |
| Article Title: | Optimizing autologous stem cell mobilization strategies to improve patient outcomes: Consensus guidelines and recommendations |
| Abstract: | Autologous hematopoietic stem cell transplantation (aHSCT) is a well-established treatment for malignancies such as multiple myeloma (MM) and lymphomas. Various changes in the field over the past decade, including the frequent use of tandem aHSCT in MM, the advent of novel therapies for the treatment of MM and lymphoma, and the addition of new stem cell mobilization techniques, have led to the need to reassess current stem cell mobilization strategies. Mobilization failures with traditional strategies are common and result in delays in treatment and increased cost and resource utilization. Recently, plerixafor-containing strategies have been shown to significantly reduce mobilization failure rates, but the ideal method to maximize stem cell yields and minimize costs associated with collection has not yet been determined. A panel of experts convened to discuss the currently available data on autologous hematopoietic stem cell mobilization and transplantation and to devise guidelines to optimize mobilization strategies. Herein is a summary of their discussion and consensus. © 2014 American Society for Blood and Marrow Transplantation. |
| Keywords: | review; nonhuman; outcome assessment; consensus; multiple myeloma; steady state; cyclophosphamide; practice guideline; hodgkin disease; health care cost; algorithm; lymphoma; stem cell mobilization; target cell; safety; blood volume; growth factor; granulocyte colony stimulating factor; plerixafor; autologous hematopoietic stem cell transplantation; stromal cell derived factor 1; randomized controlled trial (topic); phase 2 clinical trial (topic); phase 3 clinical trial (topic); apheresis; mobilization; mobilization failure; growth factors; chemokine receptor cxcr4 antagonist; human; chemomobilization; optimal collection; apheresis device |
| Journal Title: | Biology of Blood and Marrow Transplantation |
| Volume: | 20 |
| Issue: | 3 |
| ISSN: | 1083-8791 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2014-03-01 |
| Start Page: | 295 |
| End Page: | 308 |
| Language: | English |
| DOI: | 10.1016/j.bbmt.2013.10.013 |
| PROVIDER: | scopus |
| PUBMED: | 24141007 |
| DOI/URL: | |
| Notes: | Cited By (since 1996):2 -- Export Date: 1 May 2014 -- CODEN: BBMTF -- Source: Scopus |
