Tie2 and Eph receptor tyrosine kinase activation and signaling Journal Article
| Authors: | Barton, W. A.; Dalton, A. C.; Seegar, T. C. M.; Himanen, J. P.; Nikolov, D. B. |
| Article Title: | Tie2 and Eph receptor tyrosine kinase activation and signaling |
| Abstract: | The Eph and Tie cell surface receptors mediate a variety of signaling events during development and in the adult organism. As other receptor tyrosine kinases, they are activated on binding of extracellular ligands and their catalytic activity is tightly regulated on multiple levels. The Eph and Tie receptors display some unique characteristics, including the requirement of ligand-induced receptor clustering for efficient signaling. Interestingly, both Ephs and Ties can mediate different, even opposite, biological effects depending on the specific ligand eliciting the response and on the cellular context. Here we discuss the structural features of these receptors, their interactions with various ligands, as well as functional implications for downstream signaling initiation. The Eph/ephrin structures are already well reviewed and we only provide a brief overview on the initial binding events. We go into more detail discussing the Tie-angiopoietin structures and recognition. © 2014 Cold Spring Harbor Laboratory Press; all rights reserved. |
| Journal Title: | Cold Spring Harbor Perspectives in Medicine |
| Volume: | 6 |
| Issue: | 3 |
| ISSN: | 2157-1422 |
| Publisher: | Cold Spring Harbor Laboratory Press |
| Date Published: | 2014-01-01 |
| Start Page: | a009142 |
| Language: | English |
| DOI: | 10.1101/cshperspect.a009142 |
| PROVIDER: | scopus |
| PMCID: | PMC3949358 |
| PUBMED: | 24478383 |
| DOI/URL: | |
| Notes: | Cited By (since 1996):1 -- Export Date: 1 May 2014 -- Source: Scopus |
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