Hsp-27 expression at diagnosis predicts poor clinical outcome in prostate cancer independent of ETS-gene rearrangement Journal Article

   

Authors:	Foster, C. S.; Dodson, A. R.; Ambroisine, L.; Fisher, G.; Møller, H.; Clark, J.; Attard, G.; de Bono, J.; Scardino, P.; Reuter, V. E.; Cooper, C. S.; Berney, D. M.; Cuzick, J.
Article Title:	Hsp-27 expression at diagnosis predicts poor clinical outcome in prostate cancer independent of ETS-gene rearrangement
Abstract:	Background: This study was performed to test the hypothesis that expression of small heat shock protein Hsp-27 is, at diagnosis, a reliable predictive biomarker of clinically aggressive prostate cancer. Methods: A panel of tissue microarrays constructed from a well-characterised cohort of 553 men with conservatively managed prostate cancer was stained immunohistochemically to detect Hsp-27 protein. Hsp-27 expression was compared with a series of pathological and clinical parameters, including outcome. Results: Hsp-27 staining was indicative of higher Gleason score (P&lt;0.001). In tissue cores having a Gleason score &gt;7, the presence of Hsp-27 retained its power to independently predict poor clinical outcome (P&lt;0.002). Higher levels of Hsp-27 staining were almost entirely restricted to cancers lacking ERG rearrangements (χ<sup>2</sup> trend=31.4, P&lt;0.001), although this distribution did not have prognostic significance. Interpretation: This study has confirmed that, in prostate cancers managed conservatively over a period of more than 15 years, expression of Hsp-27 is an accurate and independent predictive biomarker of aggressive disease with poor clinical outcome (P&lt;0.001). These findings suggest that apoptotic and cell-migration pathways modulated by Hsp-27 may contain targets susceptible to the development of biologically appropriate chemotherapeutic agents that are likely to prove effective in treating aggressive prostate cancers. © 2009 Cancer Research UK.
Keywords:	immunohistochemistry; controlled study; human tissue; protein expression; aged; major clinical study; outcome assessment; gene; apoptosis; prostate cancer; cell migration; heat shock protein 27; parameter; prognostic biomarker; ets gene
Journal Title:	British Journal of Cancer
Volume:	101
Issue:	7
ISSN:	0007-0920
Publisher:	Nature Publishing Group
Date Published:	2009-10-06
Start Page:	1137
End Page:	1144
Language:	English
DOI:	10.1038/sj.bjc.6605227
PROVIDER:	scopus
PMCID:	PMC2768089
PUBMED:	19707199
DOI/URL:	http://www.scopus.com/inward/record.url?eid=2-s2.0-70349659461&partnerID=40&md5=e9b01a56805da928ddfa8b9fac758a29
Notes:	--- - "Cited By (since 1996): 3" - "Export Date: 30 November 2010" - "CODEN: BJCAA" - "Source: Scopus"

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