Melanomas difficult to diagnose via dermoscopy Journal Article


Authors: Rose, S. E.; Argenziano, G.; Marghoob, A. A.
Article Title: Melanomas difficult to diagnose via dermoscopy
Abstract: Due to the potentially lethal nature of melanoma, prompt diagnosis and timely excision are of paramount importance. The clinical ABCD mnemonic (asymmetry, boarder irregularity, color variegation and diameter greater than 6mm) is one of the first and most widely used methods introduced to teach early melanoma recognition. Unfortunately, some melanomas can evade the clinical ABCD rule and mimic benign melanocytic nevi or mimic benign and/or malignant variants of non-melanocytic lesions. Over the last two decades, knowledge and insight have been gained into the dermoscopic primary morphology of melanocytic and non-melanocytic lesions. This has allowed for the use of dermoscopy to substantially increase the diagnostic accuracy for melanoma over clinical naked-eye examination alone. Unfortunately, even with dermoscopy, some melanomas remain difficult to diagnose. However, these difficult to diagnose melanomas often reveal subtle dermoscopic clues that allow for their correct identification. In this review, we focus on five variants of melanoma that are challenging to identify and discuss the dermoscopic features that can assist in their diagnosis.
Keywords: clinical feature; review; cancer diagnosis; diagnostic accuracy; sensitivity and specificity; diagnostic procedure; melanoma; dermoscopy; skin neoplasms; diagnosis, differential; differential diagnosis; epiluminescence microscopy; morphology; melanocytic nevus; nevus, pigmented; predictive value of tests; seborrheic keratosis; amelanotic melanoma; early detection of cancer; skin diseases; melanoma, diagnosis; hypomelanosis
Journal Title: Giornale Italiano di Dermatologia e Venereologia
Volume: 145
Issue: 1
ISSN: 0392-0488
Publisher: Edizioni Minerva Medica  
Date Published: 2010-02-01
Start Page: 111
End Page: 126
Language: English
PUBMED: 20197750
PROVIDER: scopus
DOI/URL:
Notes: --- - "Export Date: 20 April 2011" - "CODEN: GIDVD" - "Source: Scopus"
Citation Impact
MSK Authors
  1. Ashfaq A Marghoob
    534 Marghoob