Cutaneous metastatic breast carcinoma with melanocyte colonization: A clinical and dermoscopic mimic of malignant melanoma Journal Article


Authors: Wyatt, A. J.; Agero, A. L. C.; Delgado, R.; Busam, K. J.; Marghoob, A. A.
Article Title: Cutaneous metastatic breast carcinoma with melanocyte colonization: A clinical and dermoscopic mimic of malignant melanoma
Abstract: BACKGROUND: Melanocyte colonization of breast carcinoma cells may occur in those tumors that breach the epidermal - dermal interface. The resultant melanin deposition in tumor cells rarely leads to clinical pigmentation of the tumor. Typically, selective staining methods are required to detect the pigment. OBSERVATION: The authors describe a 60-year-old woman with a history of mammary carcinoma and an irregularly pigmented nodule with peripheral globules and a blue-white veil on dermoscopy, which was a clinical and dermoscopic mimic of malignant melanoma. CONCLUSIONS: Awareness of melanocyte colonization of non-melanocytic tumor cells and the dermoscopic - histologic correlations can aid in avoiding a potential pitfall, and emphasize the importance of such relationships, when using this tool. © 2006 by the American Society for Dermatologic Surgery, Inc. Published by Blackwell Publishing.
Keywords: immunohistochemistry; adult; middle aged; clinical feature; disease course; histopathology; case report; adenocarcinoma; diagnostic procedure; melanoma; dermoscopy; skin neoplasms; melanocyte; diagnosis, differential; melanocytes; differential diagnosis; breast neoplasms; epiluminescence microscopy; correlation analysis; laboratory test; breast carcinoma; skin metastasis
Journal Title: Dermatologic Surgery
Volume: 32
Issue: 7
ISSN: 1076-0512
Publisher: Lippincott Williams & Wilkins  
Date Published: 2006-07-01
Start Page: 949
End Page: 954
Language: English
DOI: 10.1111/j.1524-4725.2006.32202.x
PUBMED: 16875480
PROVIDER: scopus
DOI/URL:
Notes: --- - "Cited By (since 1996): 8" - "Export Date: 4 June 2012" - "CODEN: DESUF" - "Source: Scopus"
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MSK Authors
  1. Anna Liza C Agero
    34 Agero
  2. Ruby Delgado
    26 Delgado
  3. Ashfaq A Marghoob
    534 Marghoob
  4. Klaus J Busam
    688 Busam