Myoblast fusion: When it takes more to make one Journal Article

Authors: Rochlin, K.; Yu, S.; Roy, S.; Baylies, M. K.
Article Title: Myoblast fusion: When it takes more to make one
Abstract: Cell-cell fusion is a crucial and highly regulated event in the genesis of both form and function of many tissues. One particular type of cell fusion, myoblast fusion, is a key cellular process that shapes the formation and repair of muscle. Despite its importance for human health, the mechanisms underlying this process are still not well understood. The purpose of this review is to highlight the recent literature pertaining to myoblast fusion and to focus on a comparison of these studies across several model systems, particularly the fly, zebrafish and mouse. Advances in technical analysis and imaging have allowed identification of new fusion genes and propelled further characterization of previously identified genes in each of these systems. Among the cellular steps identified as critical for myoblast fusion are migration, recognition, adhesion, membrane alignment and membrane pore formation and resolution. Importantly, striking new evidence indicates that orthologous genes govern several of these steps across these species. Taken together, comparisons across three model systems are illuminating a once elusive process, providing exciting new insights and a useful framework of genes and mechanisms. © 2009 Elsevier Inc.
Keywords: review; nonhuman; protein function; mitosis; mouse; animal; cytology; animals; mice; actin; cell division; cell function; cell maturation; drosophila; embryo development; cell differentiation; cell population; extracellular matrix; prenatal development; cell membrane; fusion gene; growth regulation; cell migration; branching morphogenesis; cell shape; cell adhesion; mesoderm; developmental stage; zebrafish; skeletal muscle; danio rerio; cytoskeleton protein; myoblast fusion; cell fusion; myoblast; myoblasts; muscle development; cell vacuole; orthology; drosophilia; membrane dynamics; mouse actin cystoskeleton; vesicle trafficking; muscle growth
Journal Title: Developmental Biology
Volume: 341
Issue: 1
ISSN: 0012-1606
Publisher: Elsevier Inc.  
Date Published: 2010-05-01
Start Page: 66
End Page: 83
Language: English
DOI: 10.1016/j.ydbio.2009.10.024
PUBMED: 19932206
PROVIDER: scopus
PMCID: PMC2854170
Notes: --- - "Cited By (since 1996): 10" - "Export Date: 20 April 2011" - "CODEN: DEBIA" - "Source: Scopus"
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MSK Authors
  1. Mary K Baylies
    73 Baylies
  2. Shannon Yu
    3 Yu