Inherited predisposition to cancer: Introduction and overview Journal Article
| Authors: | Robson, M.; Offit, K. |
| Article Title: | Inherited predisposition to cancer: Introduction and overview |
| Abstract: | The past three decades have witnessed an explosion in information regarding the genetic mutations underlying predisposition to common malignancies. Discoveries are now being made regarding genomic variants associated with disease risk for, and outcome following, treatment for cancer. Responsible translation of these discoveries to medical practice requires attention to principles of clinical utility as well as social and ethical aspects. © 2010 Elsevier Inc. |
| Keywords: | gene mutation; review; cancer susceptibility; genetic predisposition to disease; melanoma; breast cancer; genetic association; practice guideline; brca2 protein; cancer research; history; cancer genetics; practice guidelines as topic; nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase inhibitor; cyclin dependent kinase inhibitor 2a; genetic predisposition; genetic screening; genetic testing; neoplastic syndromes, hereditary; individualized medicine; high penetrance; brca1 associated ring domain protein 1 |
| Journal Title: | Hematology/Oncology Clinics of North America |
| Volume: | 24 |
| Issue: | 5 |
| ISSN: | 0889-8588 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2010-10-01 |
| Start Page: | 793 |
| End Page: | 797 |
| Language: | English |
| DOI: | 10.1016/j.hoc.2010.06.005 |
| PUBMED: | 20816574 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Cited By (since 1996): 1" - "Export Date: 20 April 2011" - "CODEN: HCNAE" - "Source: Scopus" |
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