Anaplastic thyroid carcinoma: Morphologic findings and PAX-8 expression in cytology specimens Journal Article
| Authors: | Rivera, M.; Shang, C.; Gerhard, R.; Ghossein, R.; Lin, O. |
| Article Title: | Anaplastic thyroid carcinoma: Morphologic findings and PAX-8 expression in cytology specimens |
| Abstract: | Objective: To evaluate the morphologic findings most encountered in anaplastic thyroid carcinomas (ATCs) and evaluate for the expression of PAX-8. Study Design: The cytology specimens from 21 cases of ATC were evaluated for the following several cytologic criteria: cell morphology, pleomorphism, presence or absence of multinucleated cells, colloid, neutrophilic infiltrate and well-differentiated component. Immunohistochemical studies for PAX-8 were performed on cell blocks in selected cases. Results: The most common morphology present was epithelioid, followed by spindle, multinucleated giant cell and rhabdoid, with 75% demonstrating more than 1 cell morphology. Marked pleomorphism (81%), neutrophilic infiltrate (90%) and necrosis (63%) were frequent. No nuclear grooves, colloid or well-differentiated component was identified in any case. Immunocytochemical stains for PAX-8 were negative in 5 cases in which a cell block was available. Conclusion: ATC is a tumor with diverse morphologic characteristics, and more than 1 cell morphology is usually present. A neutrophilic infiltrate is a common finding and represents a clue to the correct diagnosis. © The International Academy of Cytology. |
| Keywords: | human tissue; protein expression; aged; cytology; metabolism; cell death; cell structure; diagnosis, differential; differential diagnosis; cell differentiation; pathology; enzyme immunoassay; immunoenzyme techniques; needle biopsy; biopsy, fine-needle; carcinoma; thyroid cancer; thyroid carcinoma; thyroid neoplasms; giant cell; thyroid tumor; neutrophil chemotaxis; anaplastic carcinoma; cytodiagnosis; paired box transcription factor; paired box transcription factors; pax8 protein, human; giant cells; transcription factor pax8; aspiration biopsy, fine-needle; carcinoma, anaplastic; pax-8; anaplastic thyroid carcinoma; multinuclear cell |
| Journal Title: | Acta Cytologica |
| Volume: | 54 |
| Issue: | 5 |
| ISSN: | 0001-5547 |
| Publisher: | S. Karger AG |
| Date Published: | 2010-09-01 |
| Start Page: | 668 |
| End Page: | 672 |
| Language: | English |
| PUBMED: | 20968153 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Export Date: 20 April 2011" - "CODEN: ACYTA" - "Source: Scopus" |
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