Fine-needle aspiration cytology of colloid carcinoma of the pancreas Journal Article
| Authors: | Sigel, C. S.; Santos-Zabala, L.; Basturk, O. |
| Article Title: | Fine-needle aspiration cytology of colloid carcinoma of the pancreas |
| Abstract: | Colloid carcinoma is a rare invasive carcinoma of the pancreas believed to arise from intestinal-type intraductal papillary mucinous neoplasm. Previous cytologic descriptions of invasive carcinomas associated with intraductal papillary mucinous neoplasms do not uniformly specify the type of invasive carcinoma or may not use current diagnostic criteria for colloid carcinoma. We searched our archive for ultrasound-guided fine-needle aspirates of the pancreas with histologic correlation showing colloid carcinoma (defined by containing >80% extracellular mucin) and reviewed corresponding cytology and histology. We identified 7 fine-needle aspirates from resected colloid carcinomas. In 5 of 7, an associated intraductal papillary mucinous neoplasm of predominantly intestinal type was identified with the invasive component and comprising less than 10% to 100% of the mass lesion. After cytologic-histological correlation, it was determined that 5 of 7 cases contained colloid carcinoma, whereas 2 were excluded for showing discrepant features suggesting sampling error. The 5 aspirates containing colloid carcinoma uniformly showed low cellularity (tumor cells comprised <20% of smeared material), abundant thick/glassy mucin, degenerating inflammatory cells in mucin, mild nuclear membrane abnormalities, and disordered sheets. The majority (4/5, 80%) were diagnosed previously as "suspicious for mucinous neoplasm." Colloid carcinoma cytology overlaps with intraductal papillary mucinous neoplasm and may be subject to underdiagnosis because of the well-differentiated cytologic appearance, low cellularity, and thick obscuring mucin. © 2015 Wolters Kluwer Health, Inc. All rights reserved. |
| Keywords: | pancreas; colloid carcinoma; fna |
| Journal Title: | Pathology Case Reviews |
| Volume: | 20 |
| Issue: | 4 |
| ISSN: | 1082-9784 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2015-07-01 |
| Start Page: | 169 |
| End Page: | 174 |
| Language: | English |
| DOI: | 10.1097/pcr.0000000000000095 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Export Date: 3 August 2015 -- Source: Scopus |
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