Analysis of serum insulin growth factor-1 concentrations in localized osteosarcoma: A children's oncology group study Journal Article
| Authors: | Borinstein, S. C.; Barkauskas, D. A.; Bernstein, M.; Goorin, A.; Gorlick, R.; Krailo, M.; Schwartz, C. L.; Wexler, L. H.; Toretsky, J. A. |
| Article Title: | Analysis of serum insulin growth factor-1 concentrations in localized osteosarcoma: A children's oncology group study |
| Abstract: | To investigate the role of insulin-like growth factor-1 (IGF-1), in localized osteosarcoma, serum levels of IGF-1, IGFBP-2, and IGFBP-3 were measured in 224 similarly treated, newly diagnosed patients. We demonstrated that younger patients had lower concentrations of IGF-1 and IGFBP-3 compared to older (P<0.001) along with lower IGFBP-3:IGF-1 and IGFBP-2:IGF-1 ratios (P<0.001). IGFBP-2 did not correlate with age (P=0.16), yet IGFBP-2:IGF-1 ratios were higher in the younger population (P<0.001). These findings show that older patients have higher concentrations of free IGF-1. None of IGF-1, IGFBP-2, nor IGFBP-3 concentrations were associated with event-free nor overall survival. © 2013 Wiley Periodicals, Inc. |
| Keywords: | osteosarcoma; clinical trials; cancer biology |
| Journal Title: | Pediatric Blood and Cancer |
| Volume: | 61 |
| Issue: | 4 |
| ISSN: | 1545-5009 |
| Publisher: | Wiley Periodicals, Inc |
| Date Published: | 2014-04-01 |
| Start Page: | 749 |
| End Page: | 752 |
| Language: | English |
| DOI: | 10.1002/pbc.24778 |
| PROVIDER: | scopus |
| PMCID: | PMC3946315 |
| PUBMED: | 24178953 |
| DOI/URL: | |
| Notes: | Export Date: 3 March 2014 -- CODEN: PBCEA -- Source: Scopus |
