IGF-binding proteins, adiponectin, and survival in metastatic colorectal cancer: Results from CALGB (Alliance)/SWOG 80405 Journal Article
| Authors: | Guercio, B. J.; Zhang, S.; Ou, F. S.; Venook, A. P.; Niedzwiecki, D.; Lenz, H. J.; Innocenti, F.; Pollak, M. N.; Nixon, A. B.; Mullen, B. C.; O'Neil, B. H.; Shaw, J. E.; Polite, B. N.; Benson, A. B. 3rd; Atkins, J. N.; Goldberg, R. M.; Brown, J. C.; O'Reilly, E. M.; Mayer, R. J.; Blanke, C. D.; Fuchs, C. S.; Meyerhardt, J. A. |
| Article Title: | IGF-binding proteins, adiponectin, and survival in metastatic colorectal cancer: Results from CALGB (Alliance)/SWOG 80405 |
| Abstract: | Background: Energy balance-related biomarkers are associated with risk and prognosis of various malignancies. Their relationship to survival in metastatic colorectal cancer (mCRC) requires further study. Methods: Baseline plasma insulin-like growth factor (IGF)-1, IGF-binding protein (IGFBP)-3, IGFBP-7, C-peptide, and adiponectin were measured at time of trial registration in a prospective cohort of patients with mCRC participating in a National Cancer Institute-sponsored trial of first-line systemic therapy. We used Cox proportional hazards regression to adjust for confounders and examine associations of each biomarker with overall survival (OS) and progression-free survival (PFS). P values are 2-sided. Results: Median follow-up for 1086 patients was 6.2 years. Compared with patients in the lowest IGFBP-3 quintile, patients in the highest IGFBP-3 quintile experienced an adjusted hazard ratio (HR) for OS of 0.57 (95% confidence interval [CI] = 0.42 to 0.78; Pnonlinearity < .001) and for PFS of 0.61 (95% CI = 0.45 to 0.82; Ptrend = .003). Compared with patients in the lowest IGFBP-7 quintile, patients in the highest IGFBP-7 quintile experienced an adjusted hazard ratio for OS of 1.60 (95% CI = 1.30 to 1.97; Ptrend < .001) and for PFS of 1.38 (95% CI = 1.13 to 1.69; Ptrend < .001). Plasma C-peptide and IGF-1 were not associated with patient outcomes. Adiponectin was not associated with OS; there was a nonlinear U-shaped association between adiponectin and PFS (Pnonlinearity = .03). Conclusions: Among patients with mCRC, high plasma IGFBP-3 and low IGFBP-7 were associated with longer OS and PFS. Extreme levels of adiponectin were associated with shorter PFS. These findings suggest potential avenues for prognostic and therapeutic innovation. © 2021 Oxford University Press. All rights reserved. |
| Journal Title: | JNCI Cancer Spectrum |
| Volume: | 5 |
| Issue: | 1 |
| ISSN: | 2515-5091 |
| Publisher: | Oxford University Press |
| Date Published: | 2021-02-01 |
| Start Page: | pkaa074 |
| Language: | English |
| DOI: | 10.1093/jncics/pkaa074 |
| PROVIDER: | scopus |
| PMCID: | PMC7785047 |
| PUBMED: | 33426464 |
| DOI/URL: | |
| Notes: | Article -- Export Date: 1 March 2021 -- Source: Scopus |
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