Radioimmunotherapy: Current status and future directions Book Section
| Authors: | Pandit-Taskar, N.; Divgi, C. R. |
| Editor: | An, Z. |
| Article/Chapter Title: | Radioimmunotherapy: Current status and future directions |
| Abstract: | A number of new antibodies have been developed for cancer therapy in the past decade. Following approval by the U.S. Food and Drug Administration and the success of two radiolabeled antiCD20 antibodies against lymphoma, there has been renewed interest in radioimmunotherapy. Development of new radiotherapeutic agents has been most marked in the hematologic neoplasms for myeloablative or nonmyeloablative treatment strategies. However, radioimmunotherapy of solid tumors is still a challenge mostly due to tumor heterogeneity, the immunogenicity of murine proteins, and the relatively slow clearance of humanized intact immunoglobulins. Development of a variety of antigen-binding constructs though genetic engineering is being evaluated and may be more valuable due to variation in size and immunobiologic characteristics. Avariety of therapeutic radionuclides are nowavailable for use with antibodies through advances in radiochemistry enabling more optimal imaging for dosimetry. Such progress has generated pivotal studies that will establish the radiobiologic paradigms for successful radioimmunotherapy in solid tumor. This chapter describes studies that have guided a better understanding of radioimmunotherapy in solid tumors. © 2009 John Wiley & Sons, Inc. |
| Keywords: | lymphoma radioimmunotherapy - anti-cd20 antibodies; pretargeting strategies for rit; radioimmunotherapy - current status and future directions |
| Book Title: | Therapeutic Monoclonal Antibodies: From Bench to Clinic |
| ISBN: | 978-0-470-11791-0 |
| Publisher: | John Wiley & Sons |
| Publication Place: | Hoboken, NJ |
| Date Published: | 2009-01-01 |
| Start Page: | 797 |
| End Page: | 819 |
| Language: | English |
| DOI: | 10.1002/9780470485408.ch34 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | Book Chapter 34 -- 9780470117910 (ISBN) -- Export Date: 3 February 2014 -- Source: Scopus |
Altmetric
Citation Impact
BMJ Impact Analytics
MSK Authors
-
163Divgi -
342Pandit-Taskar
Related MSK Work