Current status of radioimmunotherapy Journal Article

  


Authors: Larson, S. M.; Divgi, C. R.; Scott, A.; Sgouros, G.; Graham, M. C.; Kostakoglu, L.; Scheinberg, D.; Cheung, N. K. V.; Schlom, J.; Finn, R. D.
Article Title: Current status of radioimmunotherapy
Abstract: Radioimmunotherapy with radiolabeled monoclonal antibodies is increasingly effective for hematopoietic tumors, with a number of investigators reporting persistent major responses. Radioimmunotherapy for solid tumors has been more difficult and only an occasional major response has been reported and these have so far not been persistent. Toxicity is predominantly hematopoietic, with platelets being most sensitive to the effects of radiation. Even at ultra-high doses (up to 28 mCi/kg of 131I), second organ toxicity has not been reached. Rational approaches to dose planning are becoming possible with improvements in dosimetry, based on quantitative SPECT and PET imaging. Current therapeutic indices for tumor/marrow, the most radiosensitive organ, are in the range of 5-10 to I. This is probably still too low for curative treatment of solid tumors, and further refinements, perhaps based on novel antibody formulations, are needed. © 1994.
Keywords: clinical trial; conference paper; neoplasms; phase 2 clinical trial; bone marrow suppression; monoclonal antibody; iodine 131; dosimetry; radiosensitivity; hematopoiesis; radioimmunotherapy; clinical trials; intravenous drug administration; tomography, emission-computed; tomography, emission-computed, single-photon; monoclonal antibody m 195; cancer; human; monoclonal antibody cc49
Journal Title: Nuclear Medicine and Biology
Volume: 21
Issue: 5
ISSN: 0969-8051
Publisher: Elsevier Science Inc.  
Date Published: 1994-07-01
Start Page: 785
End Page: 792
Language: English
DOI: 10.1016/0969-8051(94)90050-7
PROVIDER: scopus
PUBMED: 9241655
DOI/URL:

https://www.scopus.com/inward/record.uri?eid=2-s2.0-0028304254&doi=10.1016%2f0969-8051%2894%2990050-7&partnerID=40&md5=7f5b60ed568b2f133c3309abd7239f2c
Notes: Export Date: 14 January 2019 -- Article -- CODEN: NMBIE C2 -- Source: Scopus
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MSK Authors
  1. George Sgouros
    146 Sgouros
  2. Nai-Kong Cheung
    648 Cheung
  3. Chaitanya Divgi
    163 Divgi
  4. Ronald D Finn
    279 Finn
  5. David Scheinberg
    499 Scheinberg
  6. Steven M Larson
    958 Larson
  7. Martin C Graham
    53 Graham
  8. Lale Kostakoglu
    22 Kostakoglu
  9. Andrew M. Scott
    62 Scott
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