The clinical impact and outcomes of immunohistochemistry-only metastasis in breast cancer Journal Article
| Authors: | Pugliese, M.; Stempel, M.; Patil, S.; Hsu, M.; Ho, A.; Traina, T.; Morrow, M.; Cody, H. S. 3rd; Gemignani, M. L. |
| Article Title: | The clinical impact and outcomes of immunohistochemistry-only metastasis in breast cancer |
| Abstract: | Background: Modern surgical and pathological techniques can detect small-volume axillary metastases in breast cancer with unknown clinical significance. Methods: A retrospective database review from 1996 through 2004 identified all patients with immunohistochemical (IHC)-only sentinel node (IHC-SN) metastases and compared them with negative controls (Neg-SN). Results: When comparing the 232 IHC-SN patients with the 252 Neg-SN controls, the IHC-SN patients had larger tumors, more lobular histology, a higher grade, and more HER2/neu positivity. They also received more systemic therapy. With a median follow-up of 5 years, there were no differences in recurrence-free survival or overall survival. In 123 IHC-SN patients treated with axillary dissection (axillary lymph node dissection), 16% had positive non-SLNs. Patients with positive non-SLNs tended to have worse outcomes. Conclusions: IHC-only sentinel lymph node (SLN) metastases were associated with worse prognostic features and higher rates of systemic therapy. However, no outcomes differences were noted. © 2010 Elsevier Inc. |
| Keywords: | immunohistochemistry; adult; controlled study; human tissue; treatment outcome; aged; surgical technique; major clinical study; overall survival; systemic therapy; follow up; lymph node metastasis; antineoplastic agent; lymph node dissection; cancer grading; sentinel lymph node; sentinel lymph node biopsy; breast cancer; epidermal growth factor receptor 2; retrospective study; histology; axillary lymph node; cancer size; micrometastasis; recurrence free survival; immunohistochemical n0(i+); immunohistochemical-only sentinel lymph node; isolated tumor cells; nanometastasis |
| Journal Title: | American Journal of Surgery |
| Volume: | 200 |
| Issue: | 3 |
| ISSN: | 0002-9610 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2010-09-01 |
| Start Page: | 368 |
| End Page: | 373 |
| Language: | English |
| DOI: | 10.1016/j.amjsurg.2009.10.016 |
| PROVIDER: | scopus |
| PUBMED: | 20800716 |
| DOI/URL: | |
| Notes: | --- - "Export Date: 20 April 2011" - "CODEN: AJSUA" - "Source: Scopus" |
