Chemotherapy for the elderly patient with colorectal cancer Journal Article
| Authors: | Power, D. G.; Lichtman, S. M. |
| Article Title: | Chemotherapy for the elderly patient with colorectal cancer |
| Abstract: | Colorectal cancer is a common cancer in older patients with nearly 70% of all cases diagnosed in patients 65 years and older. Many chemotherapy clinical trials that have advanced the field in both localized and metastatic disease have not included patients from the age group most representative of the disease. Retrospective series and subset analyses show that older patients derive the same benefit from optimum multimodality strategies as their younger counterparts. Lack of prospective data and a generalization of increased toxicity rates seen in older patients with multiple comorbidities to the overall heterogenous population of older patients have lead to a reluctance to treat older patients with modern chemobiologic therapy. Despite increased comorbidities, decreased hepatic reserve, and an under-representation of older patients undergoing liver resection, the majority of published data does not support a negative correlation between poor outcome and increasing age. There is an urgent need to include older patients in clinical trials for colorectal cancer and to understand and use geriatric assessment scoring systems to identify those patients most likely to benefit from optimum treatment. Copyright © 2010 by Lippincott Williams & Wilkins. |
| Keywords: | adult; cancer chemotherapy; aged; aged, 80 and over; middle aged; clinical trial; neutropenia; review; bevacizumab; fluorouracil; cancer risk; diarrhea; drug safety; hypertension; antineoplastic agents; clinical trials as topic; liver neoplasms; capecitabine; cancer adjuvant therapy; cancer radiotherapy; chemotherapy, adjuvant; chemotherapy; cancer staging; neurotoxicity; outcome assessment; colorectal cancer; metastasis; multiple cycle treatment; bleeding; stomatitis; dexamethasone; publication; cetuximab; irinotecan; colorectal neoplasms; liver metastasis; correlation analysis; population research; thromboembolism; folinic acid; comorbidity; scoring system; neoplasm metastasis; liver resection; targeted therapy; age distribution; intestine perforation; oxaliplatin; hand foot syndrome; rectum cancer; elderly; proteinuria; geriatric assessment; metastatic; venous thromboembolism; clinical assessment tool; adjuvant; levamisole; assessment score |
| Journal Title: | The Cancer Journal |
| Volume: | 16 |
| Issue: | 3 |
| ISSN: | 1528-9117 |
| Publisher: | Lippincott Williams & Wilkins |
| Date Published: | 2010-05-01 |
| Start Page: | 241 |
| End Page: | 252 |
| Language: | English |
| DOI: | 10.1097/PPO.0b013e3181e07690 |
| PUBMED: | 20526103 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Export Date: 20 April 2011" - "CODEN: CAJOC" - "Source: Scopus" |
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