Clinical genetics of hereditary colorectal cancer Journal Article
| Authors: | Power, D. G.; Glogowski, E.; Lipkin, S. M. |
| Article Title: | Clinical genetics of hereditary colorectal cancer |
| Abstract: | Colorectal cancer (CRC) is a common disease, and approximately 25% of patients have a familial component. High-penetrance singlegene germline mutations conferring a true hereditary susceptibility account for around 5% to 6% of all cases. Lynch syndrome is the most common hereditary form of colorectal cancer. Much of the hereditary component in the remaining familial cases of CRC is likely polygenic, and many of the genetic changes involved are as yet unidentified. This article addresses the most clinically important CRC genetic syndromes. © 2010 Elsevier Inc. |
| Keywords: | immunohistochemistry; signal transduction; gene mutation; gene sequence; genetics; missense mutation; clinical trial; review; fluorouracil; cancer risk; antineoplastic agent; colorectal cancer; germline; genetic predisposition to disease; chemoprophylaxis; metastasis; gene expression; genetic association; cancer screening; dna methylation; irinotecan; colorectal neoplasms; epigenetics; cpg island; acetylsalicylic acid; celecoxib; cyclooxygenase 2 inhibitor; colorectal adenoma; folinic acid; colon cancer; mismatch repair; microsatellite instability; nonsteroid antiinflammatory agent; colon resection; nicotinamide adenine dinucleotide adenosine diphosphate ribosyltransferase inhibitor; mammalian target of rapamycin inhibitor; oxaliplatin; genetic screening; protein mlh1; lynch syndrome; protein msh2; colorectal neoplasms, hereditary nonpolyposis; cowden syndrome; genetic testing; genetic counseling; hereditary; adenomatous polyp; hormone substitution; hereditary nonpolyposis colorectal cancer; clinical medicine; neoplastic syndromes, hereditary; hereditary colorectal cancer; polyposis; hyperplastic polyposis; ileorectal anastomosis; juvenile polyp; total colon resection; hamartoma syndrome, multiple; peutz-jeghers syndrome |
| Journal Title: | Hematology/Oncology Clinics of North America |
| Volume: | 24 |
| Issue: | 5 |
| ISSN: | 0889-8588 |
| Publisher: | Elsevier Inc. |
| Date Published: | 2010-10-01 |
| Start Page: | 837 |
| End Page: | 859 |
| Language: | English |
| DOI: | 10.1016/j.hoc.2010.06.006 |
| PUBMED: | 20816577 |
| PROVIDER: | scopus |
| DOI/URL: | |
| Notes: | --- - "Export Date: 20 April 2011" - "CODEN: HCNAE" - "Source: Scopus" |
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